| Title: | Odor selectivity of hyposmia and cognitive impairment in patients with Parkinson's disease |
| Author(s): | Mao CJ; Wang F; Chen JP; Yang YP; Chen J; Huang JY; Liu CF; |
| Address: | "Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University. Institute of Neuroscience, Soochow University, Suzhou. Department of Neurology, Hospital of Changshu Traditional Chinese Medicine, Changshu, People's Republic of China" |
| ISSN/ISBN: | 1178-1998 (Electronic) 1176-9092 (Print) 1176-9092 (Linking) |
| Abstract: | "OBJECTIVE: Hyposmia is one of the earliest non-motor features of Parkinson's disease (PD) and can precede the onset of motor symptoms by years. Most of the current olfactory detection tests are targeted at Western populations. The exact relationship between hyposmia and cognitive impairment is unknown. The purpose of the study was to find bromines that can effectively identify olfactory dysfunction and investigate the relationship between hyposmia and cognitive function in early, non-demented, drug-naive patients with PD in the People's Republic of China. METHODS: Sixty-three early, non-demented, drug-naive patients with PD and 55 healthy controls were enrolled in the study. The T&T olfactometer and a Chinese version of Montreal Cognitive Assessment (MoCA) were applied to assess subjects' olfactory and cognitive functions. Patients with PD also completed the Modified Unified Parkinson's disease-rating scale (UPDRS) and Hoehn and Yahr (H&Y) scale. RESULTS: Patients with PD had lower scores of visuospatial and executive function (p=0.000), attention (p=0.03), and delayed recall (p=0.001) than controls. beta-phenylethyl alcohol (floral smell, smell of rose petals) and isovaleric acid (smell of sweat, stuffy socks) were more sensitive for identifying hyposmia in patients with PD than three other odors. Multivariate logistic regression analysis showed that impaired visuospatial and executive function was associated with hyposmia (p=0.013), but was independent of other PD-associated variables. CONCLUSION: Hyposmia was common in early, non-demented, drug-naive PD patients. beta-Phenylethyl alcohol and isovaleric acid were more superior for identifying hyposmia in early non-demented Chinese patients with PD. Hyposmia was associated with impaired visuospatial and executive function in patients with PD. Further prospective studies that apply a series of neuropsychological tests and functional magnetic resonance imaging methods in large samples in multicenter studies are needed to confirm our findings and to investigate the relationship between hyposmia and cognitive function with disease progression in patients with PD" |
| Keywords: | Aged Attention China Cognition Cognitive Dysfunction/*diagnosis/etiology Executive Function Female Humans Male Middle Aged *Odorants Olfaction Disorders/*diagnosis/etiology Parkinson Disease/*complications Prospective Studies Parkinson's disease cognitive;neuroscience; |
| Notes: | "MedlineMao, Cheng-Jie Wang, Fen Chen, Ju-Ping Yang, Ya-Ping Chen, Jing Huang, Juan-Ying Liu, Chun-Feng eng New Zealand 2017/10/27 Clin Interv Aging. 2017 Oct 9; 12:1637-1644. doi: 10.2147/CIA.S147588. eCollection 2017" |
