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Environ Geochem Health

Title:		"A cross-sectional survey based on blood VOCs, hematological parameters and urine indicators in a population in Jilin, Northeast China"
Author(s):		Li X; Guo Y; Song X; He Y; Zhang H; Bao H; Li X; Liu Y; Zhai Y; Wang J; Xu K; Li J;
Address:		"School of Public Health, Jilin Uinversity, Changchun, China. Jilin Provincial Center for Disease Control and Prevention, Changchun, China. School of Public Health, Jilin Uinversity, Changchun, China. xukun@jlu.edu.cn. School of Public Health, Jilin Uinversity, Changchun, China. li_juan@jlu.edu.cn"
Journal Title:		Environ Geochem Health
Year:		2019
Volume:		20190116
Issue:		3
Page Number:		1599 - 1615
DOI:		10.1007/s10653-019-00241-6
ISSN/ISBN:		1573-2983 (Electronic) 0269-4042 (Linking)
Abstract:		"The objective of this study was to examine whether long-term exposure to low-dose volatile organic compounds (VOCs) will have an effect on the health of non-occupational population. A total of 499 non-occupational participants aged more than 18 that live around Jilin Petrochemical Industrial Zone were chosen by stratified cluster random sampling. Their blood VOCs' levels, hematological parameters and urine indicators together with detailed questionnaire data were used to find possible relationships using binary logistic regression analysis. The detection rate of benzene in the blood was high in the non-occupational population around the industrial area, and it even reached 82.3% in males but no significant difference was recorded between male and female population. In addition, trichloroethane (male: 33.2% V female: 21.7%; p = 0.002), carbon tetrachloride (males: 20.3% V females: 7.5%; p < 0.001) and trichlorethylene (male: 34.9% V female: 24.7%; p = 0.004) all showed significant differences in gender, and without exception, the prevalence of males was higher in these three VOCs than of females. The changes in red blood cell (RBC), hematocrit (HCT) and basophils are correlated with carbon tetrachloride, trichloroethylene and chloroform, respectively. And RBC, HCT and basophils are statistically significant in male compared with female of the study population. The increase in trichlorethylene was associated with an increase of 1.723% (95% CI 1.058-2.806) in HCT. The increase in carbon tetrachloride showed a more significant correlation with an increase of 2.638% in RBC count (95% CI 1.169-5.953). And trichloromethane led to a 1.922% (95% CI 1.051-3.513) increase in basophils. The changes in urinary WBC, urine ketone (KET) and urinary bilirubin (BIL) showed significant correlation with benzene, carbon tetrachloride and dibromochloromethane, respectively. The correlation in females is more significant than in males. The increase of benzene in the female population increased urinary leukocyte count by 2.902% (95% CI 1.275-6.601). The effect of carbon tetrachloride on KET was particularly pronounced, resulting in an increase of 7.000% (95% CI 1.608-30.465). Simultaneously, an increase in dibromochloromethane caused an increase of 4.256% (95% CI 1.373-13.192) in BIL. The changes in RBC, HCT and basophils can only serve as an auxiliary indicator for disease diagnosis, so they have no significant clinical significance. However, the alteration of urinary WBC, KET and BIL has great clinical significances, and it is suggested that the monitoring of the above indicators from low-dose long-term exposure be strengthen in this area"
Keywords:		Adolescent Adult Air Pollutants/*blood/toxicity Benzene/analysis Bilirubin/urine Blood Cells/drug effects Carbon Tetrachloride/blood/toxicity China Creatinine/urine Cross-Sectional Studies Environmental Exposure/adverse effects/*analysis Female Hematocrit;
Notes:		"MedlineLi, Xiaocui Guo, Yuanyuan Song, Xiuling He, Yinghua Zhang, Huiwen Bao, Hao Li, Xinxin Liu, Yushen Zhai, Yue Wang, Juan Xu, Kun Li, Juan eng 21111011101EHH(2015)4-04/National Institute of the Environment/ JJKH20180239KJ/Education Department of Jilin Province/ 20160520167JH/Devlopment Foundatioon of Science and Technology in Jilin Province of China/ Netherlands 2019/01/17 Environ Geochem Health. 2019 Jun; 41(3):1599-1615. doi: 10.1007/s10653-019-00241-6. Epub 2019 Jan 16"