| Title: | Metabolism of plant polyphenols in the skin: beneficial versus deleterious effects |
| Author(s): | Korkina LG; Pastore S; De Luca C; Kostyuk VA; |
| Address: | "Lab. Tissue Engineering & Skin Pathophysiology, Dermatology Institute (Istituto Dermopatico dell'Immacolata IRCCS), Rome 00167, Italy. l.korkina@idi.it" |
| DOI: | 10.2174/138920008786049267 |
| ISSN/ISBN: | 1389-2002 (Print) 1389-2002 (Linking) |
| Abstract: | "Polyphenols are produced by all higher plants in order to protect them against biotic and abiotic stress such as UV radiation, temperature changes, infections, wounding, and herbivores. When in contact with human skin, polyphenols exert either curative or damaging action depending on their physical-chemical properties, bioavailability through cutaneous barrier, metabolism in the skin, and individual sensitivity. This review will focus on 1) synthesis and metabolism of polyphenols and their role in the plant physiology, 2) non-enzymatic and enzymatic polyphenol transformation in the skin, 3) polyphenols as inhibitors or inducers of inflammatory response in the skin, and 4) photo-protective versus photo-toxic effects of polyphenols. The potential consequences of these controversial effects on the use of plant polyphenols in dermatology and cosmetology will be also discussed" |
| Keywords: | Animals Anti-Inflammatory Agents/pharmacology Biological Availability Biotransformation Flavonoids/*metabolism/pharmacology/toxicity Humans Phenols/*metabolism/pharmacology/toxicity Plant Physiological Phenomena Plants/*chemistry Polyphenols Skin/drug eff; |
| Notes: | "MedlineKorkina, Liudmila G Pastore, Saveria De Luca, Chiara Kostyuk, Vladimir A eng Review Netherlands 2008/10/16 Curr Drug Metab. 2008 Oct; 9(8):710-29. doi: 10.2174/138920008786049267" |
