| Title: | Multisensory Logic of Infant-Directed Aggression by Males |
| Author(s): | Isogai Y; Wu Z; Love MI; Ahn MH; Bambah-Mukku D; Hua V; Farrell K; Dulac C; |
| Address: | "Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA; Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London W1T 4JG, UK. Electronic address: y.isogai@ucl.ac.uk. Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London W1T 4JG, UK. Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: dulac@fas.harvard.edu" |
| DOI: | 10.1016/j.cell.2018.11.032 |
| ISSN/ISBN: | 1097-4172 (Electronic) 0092-8674 (Print) 0092-8674 (Linking) |
| Abstract: | "Newborn mice emit signals that promote parenting from mothers and fathers but trigger aggressive responses from virgin males. Although pup-directed attacks by males require vomeronasal function, the specific infant cues that elicit this behavior are unknown. We developed a behavioral paradigm based on reconstituted pup cues and showed that discrete infant morphological features combined with salivary chemosignals elicit robust male aggression. Seven vomeronasal receptors were identified based on infant-mediated activity, and the involvement of two receptors, Vmn2r65 and Vmn2r88, in infant-directed aggression was demonstrated by genetic deletion. Using the activation of these receptors as readouts for biochemical fractionation, we isolated two pheromonal compounds, the submandibular gland protein C and hemoglobins. Unexpectedly, none of the identified vomeronasal receptors and associated cues were specific to pups. Thus, infant-mediated aggression by virgin males relies on the recognition of pup's physical traits in addition to parental and infant chemical cues" |
| Keywords: | "*Aggression Animals Animals, Newborn Gene Deletion Male Mice Mice, Mutant Strains Vomeronasal Organ/*metabolism aggression chemosensory receptors infanticide infants parenting parents pheromones sensory detection social behavior vomeronasal;" |
| Notes: | "MedlineIsogai, Yoh Wu, Zheng Love, Michael I Ahn, Michael Ho-Young Bambah-Mukku, Dhananjay Hua, Vivian Farrell, Karolina Dulac, Catherine eng R01 DC013087/DC/NIDCD NIH HHS/ R01 DC003903/DC/NIDCD NIH HHS/ R01 HD082131/HD/NICHD NIH HHS/ Wellcome Trust/United Kingdom P01 CA142538/CA/NCI NIH HHS/ HHMI_/Howard Hughes Medical Institute/ T32 CA009337/CA/NCI NIH HHS/ K99 HD092542/HD/NICHD NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2018/12/15 Cell. 2018 Dec 13; 175(7):1827-1841.e17. doi: 10.1016/j.cell.2018.11.032" |
