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Proc Natl Acad Sci U S A

Title:		Natural variation in Pristionchus pacificus insect pheromone attraction involves the protein kinase EGL-4
Author(s):		Hong RL; Witte H; Sommer RJ;
Address:		"Department for Evolutionary Biology, Max Planck-Institute for Developmental Biology, 72076 Tubingen, Germany"
Journal Title:		Proc Natl Acad Sci U S A
Year:		2008
Volume:		20080528
Issue:		22
Page Number:		7779 - 7784
DOI:		10.1073/pnas.0708406105
ISSN/ISBN:		1091-6490 (Electronic) 0027-8424 (Print) 0027-8424 (Linking)
Abstract:		"The geographical mosaic theory of coevolution predicts that different local species interactions will shape population traits, but little is known about the molecular factors involved in mediating the specificity of these interactions. Pristionchus nematodes associate with different scarab beetles around the world, with Pristionchus pacificus isolated primarily from the oriental beetle in Japan. In particular, the constituent populations of P. pacificus represent a rare opportunity to study multiple specialized interactions and the mechanisms that influence population traits at the genetic level. We identified a component of the cGMP signaling pathway to be involved in the natural variation for sensing the insect pheromone ETDA, using targeted introgression lines, exogenous cGMP treatment, and a null egl-4 allele. Our data strongly implicate egl-4 as one of several loci involved in behavioral variation in P. pacificus populations. That EGL-4 homologs have been independently implicated for behavioral variations in other invertebrate models suggests that EGL-4 may act as a modulator for interspecies behavioral repertoires across large phylogenetic distances"
Keywords:		"Alleles Amino Acid Sequence Animals Behavior, Animal *Biodiversity Biological Evolution Coleoptera/*metabolism Cyclic GMP/metabolism/pharmacology Cyclic GMP-Dependent Protein Kinases/genetics/*physiology Fatty Acids, Monounsaturated/*metabolism Gene Expre;"
Notes:		"MedlineHong, Ray L Witte, Hanh Sommer, Ralf J eng Research Support, Non-U.S. Gov't 2008/05/30 Proc Natl Acad Sci U S A. 2008 Jun 3; 105(22):7779-84. doi: 10.1073/pnas.0708406105. Epub 2008 May 28"