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Can J Microbiol

Title:		The effects of fungal volatile organic compounds on bone marrow stromal cells
Author(s):		Hokeness K; Kratch J; Nadolny C; Aicardi K; Reid CW;
Address:		"Department of Science and Technology, Bryant University, 1150 Douglas Pike, Smithfield, RI 02917, USA"
Journal Title:		Can J Microbiol
Year:		2014
Volume:		20131115
Issue:		1
Page Number:		1 - 4
DOI:		10.1139/cjm-2013-0708
ISSN/ISBN:		1480-3275 (Electronic) 0008-4166 (Print) 0008-4166 (Linking)
Abstract:		"Evidence has shown that individuals exposed to indoor toxic molds for extended periods of time have elevated risk of developing numerous respiratory illnesses. It is not clear at the cellular level what impact mold exposure has on the immune system. Herein, we show that 2 fungal volatiles (E)-2-octenal and oct-1-en-3-ol have cytotoxic effects on murine bone marrow stromal cells. To further analyze alterations to the cell, we evaluated the impact these volatile organic compounds have on membrane composition and hence fluidity. Both (E)-2-octenal and oct-1-en-3-ol exposure caused a shift to unsaturated fatty acids and lower cholesterol levels in the membrane. This indicates that the volatile organic compounds under investigation increased membrane fluidity. These vast changes to the cell membrane are known to contribute to the breakdown of normal cell function and possibly lead to death. Since bone marrow stromal cells are vital for the appropriate development and activation of immune cells, this study provides the foundation for understanding the mechanism at a cellular level for how mold exposure can lead to immune-related disease conditions"
Keywords:		*Air Microbiology Aldehydes/*toxicity Animals Cell Line Fungi/*chemistry Humans Membrane Fluidity/drug effects Mesenchymal Stem Cells/*drug effects Mice Octanols/*toxicity Volatile Organic Compounds/*toxicity;
Notes:		"MedlineHokeness, Kirsten Kratch, Jacqueline Nadolny, Christina Aicardi, Kristie Reid, Christopher W eng P20 GM103430/GM/NIGMS NIH HHS/ 8 P20 GM103430-12/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Canada 2014/01/08 Can J Microbiol. 2014 Jan; 60(1):1-4. doi: 10.1139/cjm-2013-0708. Epub 2013 Nov 15"