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Carbohydr Polym

Title:		Effects of fructans and probiotics on the inhibition of Klebsiella oxytoca and the production of short-chain fatty acids assessed by NMR spectroscopy
Author(s):		Higashi B; Mariano TB; de Abreu Filho BA; Goncalves RAC; de Oliveira AJB;
Address:		"Graduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringa, Ave. Colombo 5790, 87.020-900, Maringa, Brazil. Departament of Basic Health Sciences, State University of Maringa, Ave. Colombo 5790, 87.020-900, Maringa, Brazil. Graduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringa, Ave. Colombo 5790, 87.020-900, Maringa, Brazil. Electronic address: ajboliveira@uem.br"
Journal Title:		Carbohydr Polym
Year:		2020
Volume:		20200727
Issue:
Page Number:		116832 -
DOI:		10.1016/j.carbpol.2020.116832
ISSN/ISBN:		1879-1344 (Electronic) 0144-8617 (Linking)
Abstract:		"Generally, the selection of fructans prebiotics and probiotics for the formulation of a symbiotic has been based on arbitrary considerations and in vitro tests that fail to take into account competitiveness and other interactions with autochthonous members of the intestinal microbiota. However, such analyzes may be a valuable step in the development of the symbiotic. The present study, therefore, aims to investigate the effect of lactobacilli strains and fructans (prebiotic compounds) on the growth of the intestinal competitor Klebsiella oxytoca, and to assess the correlation with short-chain fatty acids production. The short-chain fatty acids formed in the fermentation of the probiotic/prebiotic combination were investigated using NMR spectroscopy, and the inhibitory activities were assessed by agar diffusion and co-culture methods. The results showed that Lactobacillus strains can inhibit K. oxytoca, and that this antagonism is influenced by the fructans source and probably associated with organic acid production"
Keywords:		"Fatty Acids, Volatile/*metabolism Fermentation/physiology Fructans/*analysis Gastrointestinal Microbiome/physiology Gastrointestinal Tract/metabolism/microbiology Klebsiella oxytoca/*physiology/ultrastructure Lactobacillus acidophilus/physiology/ultrastru;"
Notes:		"MedlineHigashi, Bruna Mariano, Tamara Borges de Abreu Filho, Benicio Alves Goncalves, Regina Aparecida Correia de Oliveira, Arildo Jose Braz eng England 2020/09/14 Carbohydr Polym. 2020 Nov 15; 248:116832. doi: 10.1016/j.carbpol.2020.116832. Epub 2020 Jul 27"