| Title: | Non-invasive Detection of Bladder Tumors Through Volatile Organic Compounds: A Pilot Study with an Electronic Nose |
| Author(s): | Heers H; Gut JM; Hegele A; Hofmann R; Boeselt T; Hattesohl A; Koczulla AR; |
| Address: | "Department of Urology and Paediatric Urology, Philipps-Universitat Marburg, Marburg, Germany heers@med.uni-marburg.de. Department of Urology and Paediatric Urology, Philipps-Universitat Marburg, Marburg, Germany. Department of Pulmonology, Philipps-Universitat Marburg, Marburg, Germany" |
| DOI: | 10.21873/anticanres.12291 |
| ISSN/ISBN: | 1791-7530 (Electronic) 0250-7005 (Linking) |
| Abstract: | "BACKGROUND/AIM: Cystoscopy, the standard diagnostic for bladder tumors, is uncomfortable, invasive, and expensive. The available urine-based marker systems all lack accuracy. Measuring volatile organic compounds (VOCs) from urine is a promising alternative. This pilot study evaluates the feasibility of discriminating bladder cancer patients' urine from healthy controls with an electronic nose. MATERIALS AND METHODS: Headspace measurements of urine samples of 30 patients with confirmed transitional cell carcinoma (TCC) and 30 healthy controls were performed with Cyranose 320 calculating Mahalanobis distance and linear discriminant analysis. Histology reports following TUR-BT were correlated with urine findings. RESULTS: After storage at -20 degrees C, Cyranose correctly detected 28/30 already confirmed TCC samples and 26/30 healthy controls (p<0.01), sensitivity 93.3%, specificity 86.7%. Storage at -80 degrees C led to similar results: 28/30 tumor samples and 28/30 control samples were correctly allocated; sensitivity and specificity both 93.3%. CONCLUSION: VOC detection is a promising tool to detect bladder tumors. Further research will test against possible confounders like bacteriuria" |
| Keywords: | "Aged Carcinoma, Transitional Cell/diagnosis/pathology/*urine Case-Control Studies *Electronic Nose Feasibility Studies Female Humans Male Pilot Projects Urinary Bladder Neoplasms/diagnosis/pathology/*urine Volatile Organic Compounds/analysis/*urine Bladde;" |
| Notes: | "MedlineHeers, Hendrik Gut, Josef Maximilian Hegele, Axel Hofmann, Rainer Boeselt, Tobias Hattesohl, Akira Koczulla, Andreas Rembert eng Greece 2018/01/29 Anticancer Res. 2018 Feb; 38(2):833-837. doi: 10.21873/anticanres.12291" |
