| Title: | Elevated levels of volatile organic carcinogen and toxicant biomarkers in Chinese women who regularly cook at home |
| Author(s): | Hecht SS; Seow A; Wang M; Wang R; Meng L; Koh WP; Carmella SG; Chen M; Han S; Yu MC; Yuan JM; |
| Address: | "Masonic Cancer Center, University of Minnesota, School of Public Health, MMC 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA. hecht002@umn.edu" |
| Journal Title: | Cancer Epidemiol Biomarkers Prev |
| DOI: | 10.1158/1055-9965.EPI-09-1291 |
| ISSN/ISBN: | 1538-7755 (Electronic) 1055-9965 (Print) 1055-9965 (Linking) |
| Abstract: | "BACKGROUND: Epidemiologic studies associate lung cancer in nonsmoking Chinese women with Chinese-style wok cooking. Our goal was to quantify carcinogen and toxicant biomarkers in Chinese women who reported regularly doing home cooking compared with women randomly selected from the Singapore Chinese Health Study as controls. METHODS: Biomarkers were quantified by high-performance liquid chromatography-mass spectrometry, high-performance liquid chromatography with fluorescence detection, and gas chromatography-mass spectrometry. RESULTS: Compared with controls, women who engaged in regular home cooking had significantly higher levels of mercapturic acids of acrolein geometric mean, 1,959 pmol/mg creatinine [95% confidence interval (95% CI), 1,554-2,467] versus 1,370 (95% CI, 1,077-1,742); P=0.038, crotonaldehyde [geometric mean, 232 pmol/mg creatinine (95% CI, 193-277) versus 142 (95% CI, 118-171); P=0.0004], and benzene [geometric mean, 0.58 pmol/mg creatinine (95% CI, 0.44-0.78) versus 0.18 (95% CI, 0.14-0.24); P<0.0001]. No significant differences were found in levels of mercapturic acids of 1,3-butadiene, metabolites of pyrene and phenanthrene, or acetaldehyde-leukocyte DNA adduct levels between the groups. Levels of the ethylene oxide mercapturic acid were significantly higher in the controls. CONCLUSIONS: The higher levels of the mercapturic acid of benzene, a multiorgan carcinogen, in the women who cooked are particularly notable. Overall, the results showing increased exposure to the volatile toxicants and carcinogens acrolein, crotonaldehyde, and benzene in Chinese women who regularly cook provide a plausible lead for further investigating the role of volatile compounds generated during high-temperature cooking with oils as causes of lung cancer. IMPACT: A new direction for research on lung cancer etiology is suggested" |
| Keywords: | "Biomarkers/*urine Carcinogens/*metabolism China/epidemiology Chromatography, High Pressure Liquid *Cooking Female Gas Chromatography-Mass Spectrometry Hot Temperature Humans Lung Neoplasms/*chemically induced/epidemiology Middle Aged Oils, Volatile/*adver;" |
| Notes: | "MedlineHecht, Stephen S Seow, Adeline Wang, Mingyao Wang, Renwei Meng, Lei Koh, Woon-Puay Carmella, Steven G Chen, Menglan Han, Shaomei Yu, Mimi C Yuan, Jian-Min eng CA-77598/CA/NCI NIH HHS/ P30 CA077598/CA/NCI NIH HHS/ R01 ES011297-08/ES/NIEHS NIH HHS/ R01 CA080205/CA/NCI NIH HHS/ ES-11297/ES/NIEHS NIH HHS/ CA-80205/CA/NCI NIH HHS/ R01 ES011297/ES/NIEHS NIH HHS/ Randomized Controlled Trial Research Support, N.I.H., Extramural 2010/04/22 Cancer Epidemiol Biomarkers Prev. 2010 May; 19(5):1185-92. doi: 10.1158/1055-9965.EPI-09-1291. Epub 2010 Apr 20" |
