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Genes Dev

Title:		Dendritic Eph organizes dendrodendritic segregation in discrete olfactory map formation in Drosophila
Author(s):		Anzo M; Sekine S; Makihara S; Chao K; Miura M; Chihara T;
Address:		"Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan. Japan Agency for Medical Research and Development (AMED)-CREST, Japan Agency for Medical Research and Development, Chiyoda-ku, Tokyo 100-0004, Japan. Department of Biological Science, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526, Japan"
Journal Title:		Genes Dev
Year:		2017
Volume:		31
Issue:		10
Page Number:		1054 - 1065
DOI:		10.1101/gad.297424.117
ISSN/ISBN:		1549-5477 (Electronic) 0890-9369 (Print) 0890-9369 (Linking)
Abstract:		"Proper function of the neural network results from the precise connections between axons and dendrites of presynaptic and postsynaptic neurons, respectively. In the Drosophila olfactory system, the dendrites of projection neurons (PNs) stereotypically target one of approximately 50 glomeruli in the antennal lobe (AL), the primary olfactory center in the brain, and form synapses with the axons of olfactory receptor neurons (ORNs). Here, we show that Eph and Ephrin, the well-known axon guidance molecules, instruct the dendrodendritic segregation during the discrete olfactory map formation. The Eph receptor tyrosine kinase is highly expressed and localized in the glomeruli related to reproductive behavior in the developing AL. In one of the pheromone-sensing glomeruli (DA1), the Eph cell-autonomously regulates its dendrites to reside in a single glomerulus by interacting with Ephrins expressed in adjacent PN dendrites. Our data demonstrate that the trans interaction between dendritic Eph and Ephrin is essential for the PN dendritic boundary formation in the DA1 olfactory circuit, potentially enabling strict segregation of odor detection between pheromones and the other odors"
Keywords:		"Animals Dendrites/enzymology/physiology Drosophila Proteins/genetics/metabolism Drosophila melanogaster/embryology/enzymology/genetics/*physiology Gene Expression Profiling Gene Expression Regulation, Developmental Gene Knockdown Techniques Membrane Prote;"
Notes:		"MedlineAnzo, Marie Sekine, Sayaka Makihara, Shirin Chao, Kinhong Miura, Masayuki Chihara, Takahiro eng Research Support, Non-U.S. Gov't 2017/06/24 Genes Dev. 2017 May 15; 31(10):1054-1065. doi: 10.1101/gad.297424.117"