| Title: | Altered Volatile Organic Compound Profile in Transgenic Rats Bearing A53T Mutation of Human alpha-Synuclein: Comparison with Dopaminergic and Serotonergic Denervation |
| Author(s): | Finberg JPM; Aluf Y; Loboda Y; Nakhleh MK; Jeries R; Abud-Hawa M; Zubedat S; Avital A; Khatib S; Vaya J; Haick H; |
| Address: | "Neuroscience Department, Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology , Haifa 3200003, Israel. Department of Chemical Engineering, Technion - Israel Institute of Technology , Haifa 3200003, Israel. Laboratory of Natural Medicinal Compounds, Migal-Galilee Research Institute, Kiryat Shmona and Tel Hai College , Qiryat Shemona, 1220800, Israel" |
| DOI: | 10.1021/acschemneuro.7b00318 |
| ISSN/ISBN: | 1948-7193 (Electronic) 1948-7193 (Linking) |
| Abstract: | "Early diagnosis of Parkinson's disease (PD) is of great importance due its progressive phenotype. Neuroprotective drugs could potentially slow down disease progression if used at early stages. Previously, we have reported an altered content of volatile organic compounds (VOCs) in the breath of rats following a 50% reduction in striatal dopamine (DA) content induced by 6-hydroxydopamine. We now report on the difference in the breath-print and content of VOCs between rats with mild and severe lesions of DA neurons, serotonergic neuronal lesions, and transgenic (Tg) rats carrying the PD-producing A53T mutation of the SNCA (alpha-synuclein) gene. The Tg rats had an increased content of 3-octen-1-ol and 4-chloro-3-methyl phenol in blood, while in brain tissue, hexanal, hexanol, and 2,3-octanedione were present in controls but absent in Tg rats. Levels of 1-heptyl-2-methyl cyclopropane were increased in brain tissue of Tg rats. The data confirm the potential of breath analysis for detection of human idiosyncratic as well as autosomal dominant PD" |
| Keywords: | "5, 7-Dihydroxytryptamine Animals *Breath Tests Corpus Striatum/chemistry/metabolism Discriminant Analysis Dopaminergic Neurons/metabolism/pathology Factor Analysis, Statistical Male Mutation Oxidopamine Parkinsonian Disorders/*diagnosis/metabolism/patholog;" |
| Notes: | "MedlineFinberg, John P M Aluf, Yuval Loboda, Yelena Nakhleh, Morad K Jeries, Raneen Abud-Hawa, Manal Zubedat, Salman Avital, Avi Khatib, Soliman Vaya, Jacob Haick, Hossam eng Chief Scientist Office/United Kingdom Comparative Study Research Support, Non-U.S. Gov't 2017/10/11 ACS Chem Neurosci. 2018 Feb 21; 9(2):291-297. doi: 10.1021/acschemneuro.7b00318. Epub 2017 Oct 19" |
