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Folia Microbiol (Praha)

Title:		Analysis of the effects of mesoporous silica particles SBA-15 and SBA-16 in Streptococcus pneumoniae transformation process
Author(s):		Amstalden MK; Oliveira JD; Strauss M; Mazali IO; Machado D; Theisen TH; Lancellotti M;
Address:		"Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil. Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, SP, Brazil. Brazilian Nanotechnology National Laboratory, National Center for Research in Energy and Materials, Campinas, SP, Brazil. Functional Materials Laboratory, Institute of Chemistry, University of Campinas, Campinas, SP, Brazil. Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil. marcelo.lancellotti@fcf.unicamp.br. Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, SP, Brazil. marcelo.lancellotti@fcf.unicamp.br"
Journal Title:		Folia Microbiol (Praha)
Year:		2019
Volume:		20180714
Issue:		1
Page Number:		127 - 132
DOI:		10.1007/s12223-018-0631-2
ISSN/ISBN:		1874-9356 (Electronic) 0015-5632 (Linking)
Abstract:		"Streptococcus pneumoniae are natural competent bacteria which requires the presence of a pheromone-like molecule to do the transformation process. This study verified the influence of mesoporous silica (SBA-15 and SBA-16) on the transformation process in S. pneumoniae using a donor DNA obtained from a mutant strain of this microorganism (Sp360?OsluxS). The results showed that mesoporous silica SBA-15 and SBA-16 particles doubled the transformation ratio frequency compared with negative control (without nanoparticles) in using SBA-15 (ratio 1.81 +/- 0.04) and SBA-16 (ratio 2.18 +/- 0.22). We demonstrated the how mesoporous silica nanoparticles were able to increase the pneumococcus transformations, which could possibly lead to the acquisition of virulence factor genes and resistance of antibiotics"
Keywords:		"Air Pollutants/chemistry/*pharmacology Escherichia coli/drug effects/genetics Particle Size Plasmids/genetics Silicon Dioxide/chemistry/*pharmacology Streptococcus pneumoniae/*drug effects/*genetics Surface Properties Transformation, Bacterial/*drug effec;"
Notes:		"MedlineAmstalden, Maria-Cecilia Krahenbuhl Oliveira, Jose Diogo Strauss, Mathias Mazali, Italo Odone Machado, Daisy Theisen, Thais Holtz Lancellotti, Marcelo eng 2011/14079-2/FAPESP/ 2012/15046-3/FAPESP/ 2018/07/17 Folia Microbiol (Praha). 2019 Jan; 64(1):127-132. doi: 10.1007/s12223-018-0631-2. Epub 2018 Jul 14"