| Title: | N(epsilon)-(carboxymethyl)lysine Concentration in Debris from Carotid Artery Stenting Correlates Independently with Signal Intensity on T1-Weighted Black-Blood Magnetic Resonance Images |
| Author(s): | Eto A; Sakata N; Nagai R; Shirakawa JI; Inoue R; Kiyomi F; Nii K; Aikawa H; Iko M; Tsutsumi M; Sakamoto K; Hiraoka F; Mitsutake T; Hanada H; Kazekawa K; |
| Address: | "Department of Neurosurgery, Fukuoka University Chikushi Hospital, Fukuoka, Japan. General Medical Research Center, Faculty of Medicine, Fukuoka University, Fukuoka, Japan. Laboratory of Food and Regulation Biology, Department of Bioscience, School of Agriculture, Tokai University, Kumamoto, Japan. Academia, Industry and Government Collaborative Research Institute of Translational Medicine for Life Innovation, Fukuoka University, Fukuoka, Japan. Department of Neurosurgery, Fukuoka University Chikushi Hospital, Fukuoka, Japan. Electronic address: k.nii@cis.fukuoka-u.ac.jp" |
| DOI: | 10.1016/j.jstrokecerebrovasdis.2017.02.005 |
| ISSN/ISBN: | 1532-8511 (Electronic) 1052-3057 (Linking) |
| Abstract: | "BACKGROUND AND PURPOSE: Because magnetic resonance imaging (MRI) focuses on the morphological characteristics of carotid artery plaques, its diagnostic value with respect to plaque vulnerability is limited. We examined the correlation between N(epsilon)-(carboxymethyl)lysine (CML), a main chemical structure of advanced glycation end-products, and the vulnerability of plaques visualized on MRI scans. MATERIALS AND METHODS: We enrolled 43 patients who had undergone carotid artery stenting (CAS) for carotid artery stenosis; all underwent MRI studies, including black-blood MRI and diffusion-weighted imaging (DWI). The signal intensity ratio (SIR) of plaques to adjacent sternocleidomastoid muscle (P/M) on T1- and T2-weighted images (T1WI, T2WI) was calculated. Protein samples were extracted from debris trapped by a filter device. The concentrations of CML and myeloperoxidase (MPO) were measured by solid-phase enzyme-linked immunosorbent assay. RESULTS: The patients were classified into 2 groups based on their SIR-P/M on T1WI and T2WI scans. We observed a higher incidence of post-CAS DWI lesions in patients with a higher than a lower SIR-P/M on T1WI; the CML and MPO concentrations in their CAS debris were also higher. No such differences were seen in patients with a higher or lower SIR-P/M on T2WI scans. The concentration of CML in CAS debris correlated independently with the SIR-P/M on T1WI of the carotid plaques, and was related to the concentration of MPO in CAS debris. CONCLUSIONS: Our findings suggest CML as a candidate molecular imaging probe for the identification of vulnerable plaques" |
| Keywords: | "Aged Aged, 80 and over Biomarkers/blood Carotid Arteries/chemistry/*diagnostic imaging Carotid Stenosis/blood/complications/diagnostic imaging/*therapy Chi-Square Distribution Chromatography, Liquid *Diffusion Magnetic Resonance Imaging *Embolic Protectio;" |
| Notes: | "MedlineEto, Ayumu Sakata, Noriyuki Nagai, Ryoji Shirakawa, Jun-Ichi Inoue, Ritsurou Kiyomi, Fumiaki Nii, Kouhei Aikawa, Hiroshi Iko, Minoru Tsutsumi, Masanori Sakamoto, Kimiya Hiraoka, Fumihiro Mitsutake, Takahumi Hanada, Hayatsura Kazekawa, Kiyoshi eng 2017/03/21 J Stroke Cerebrovasc Dis. 2017 Jun; 26(6):1341-1348. doi: 10.1016/j.jstrokecerebrovasdis.2017.02.005. Epub 2017 Mar 14" |
