| Title: | Development of a non-invasive exhaled breath test for the diagnosis of head and neck cancer |
| Author(s): | Dharmawardana N; Goddard T; Woods C; Watson DI; Ooi EH; Yazbeck R; |
| Address: | "Department of Otorhinolaryngology-Head and Neck Surgery, Flinders Medical Centre, Bedford Park, Australia. nuwansd@gmail.com. Discipline of Surgery, College of Medicine and Public Health, Flinders University, Bedford Park, Australia. nuwansd@gmail.com. Department of Respiratory and Sleep Medicine, Women's and Children's Hospital, North Adelaide, Australia. Department of Otorhinolaryngology-Head and Neck Surgery, Flinders Medical Centre, Bedford Park, Australia. Discipline of Surgery, College of Medicine and Public Health, Flinders University, Bedford Park, Australia" |
| DOI: | 10.1038/s41416-020-01051-9 |
| ISSN/ISBN: | 1532-1827 (Electronic) 0007-0920 (Print) 0007-0920 (Linking) |
| Abstract: | "BACKGROUND: Improving the ability to identify early-stage head and neck squamous cell carcinoma (HNSCC) can improve treatment outcomes and patient morbidity. We sought to determine the diagnostic accuracy of breath analysis as a non-invasive test for detecting HNSCC. METHODS: Standardised breath samples were collected from 181 patients suspected of HNSCC prior to any treatment. A selected ion flow-tube mass spectrometer was used to analyse breath for volatile organic compounds. Diagnosis was confirmed by histopathology. A binomial logistic regression model was used to differentiate breath profiles between cancer and control (benign disease) patients based on mass spectrometry derived variables. RESULTS: In all, 66% of participants had early-stage primary tumours (T1 and T2) and 58% had regional node metastasis. The optimised logistic regression model using three variables had a sensitivity and specificity of 80% and 86%, respectively, with an AUC for ROC curve of 0.821 (95%CI 0.625-1.0) in the testing cohort. CONCLUSIONS: Breath analysis for non-invasive diagnosis of HNSCC appears to be practical and accurate. Future studies should be conducted in a primary care setting to determine the applicability of breath analysis for early identification of HNSCC" |
| Keywords: | "Adult Aged Aged, 80 and over Area Under Curve Breath Tests/*methods Early Detection of Cancer/*methods Exhalation Female Head and Neck Neoplasms/*diagnosis/pathology Humans Logistic Models Lymphatic Metastasis Male Mass Spectrometry Middle Aged Neoplasm S;" |
| Notes: | "MedlineDharmawardana, Nuwan Goddard, Thomas Woods, Charmaine Watson, David I Ooi, Eng H Yazbeck, Roger eng ASSRS/Garnett Passe and Rodney Williams Memorial Foundation (Garnett Passe & Rodney Williams Memorial Foundation)/ Multicenter Study Research Support, Non-U.S. Gov't England 2020/09/10 Br J Cancer. 2020 Dec; 123(12):1775-1781. doi: 10.1038/s41416-020-01051-9. Epub 2020 Sep 9" |
