| Title: | Early mood behavioral changes following exposure to monotonous environment during isolation stress is associated with altered hippocampal synaptic plasticity in male rats |
| Author(s): | Das SK; Baitharu I; Barhwal K; Hota SK; Singh SB; |
| Address: | "Defence Institute of High Altitude Research, DRDO, Jammu and Kashmir, India. Department of Environmental Sciences, Sambalpur University, Odisha, India. Defence Institute of Physiology and Allied Sciences, DRDO, New Delhi, India. Electronic address: drshashisingh@gmail.com" |
| DOI: | 10.1016/j.neulet.2015.12.038 |
| ISSN/ISBN: | 1872-7972 (Electronic) 0304-3940 (Linking) |
| Abstract: | "Social isolation stress and its effect on mood have been well reported, but the effect of monotony (a state of repetition of events for a considerable period of time without variation) on mood and hippocampal synaptic plasticity needs to be addressed. Present study was conducted on male Sprague-Dawley rats. Singly housed (SH) rats were subjected to monotony stress by physical, visual and pheromonal separation in specially designed animal segregation chamber. Fluoxetine (a selective serotonin reuptake inhibitor) was administered orally. Behavioral assessment showed anxiety and depression like traits in SH group. Monotony stress exposure to SH group resulted in increased pyknosis, decreased apical dendritic arborization and increased asymmetric (excitatory) synapses with the corresponding decrease in the symmetric (inhibitory) synapses in the hippocampal CA3 region. Monotonous environment during isolation stress also decreased the serotonin level and reduced the expression of synaptophysin and pCREB in the hippocampus. Fluoxetine administration to singly housed rats resulted in amelioration of altered mood along with improvement in serotonin and decrease in excitatory synaptic density but no change in altered inhibitory synaptic density in the hippocampus. These findings suggest that monotony during isolation contributes to early impairment in mood state by altering hippocampal synaptic density and neuronal morphology" |
| Keywords: | "Affect Animals Behavior, Animal Environment Fluoxetine/pharmacology Hippocampus/metabolism/*physiopathology/ultrastructure Male *Neuronal Plasticity Neurons/metabolism/ultrastructure Rats, Sprague-Dawley Serotonin/metabolism Selective Serotonin Reuptake I;" |
| Notes: | "MedlineDas, Saroj Kumar Baitharu, Iswar Barhwal, Kalpana Hota, Sunil Kumar Singh, Shashi Bala eng Research Support, Non-U.S. Gov't Ireland 2016/01/03 Neurosci Lett. 2016 Jan 26; 612:231-237. doi: 10.1016/j.neulet.2015.12.038. Epub 2015 Dec 23" |
