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Biotechnol Adv

Title:		Cell growth and cell cycle in Saccharomyces cerevisiae: basic regulatory design and protein-protein interaction network
Author(s):		Alberghina L; Mavelli G; Drovandi G; Palumbo P; Pessina S; Tripodi F; Coccetti P; Vanoni M;
Address:		"Dipartimento di Biotecnologie e Bioscienze, Universita di Milano-Bicocca, Milano, Italy. lilia.alberghina@unimib.it"
Journal Title:		Biotechnol Adv
Year:		2012
Volume:		20110722
Issue:		1
Page Number:		52 - 72
DOI:		10.1016/j.biotechadv.2011.07.010
ISSN/ISBN:		1873-1899 (Electronic) 0734-9750 (Linking)
Abstract:		"In this review we summarize the major connections between cell growth and cell cycle in the model eukaryote Saccharomyces cerevisiae. In S. cerevisiae regulation of cell cycle progression is achieved predominantly during a narrow interval in the late G1 phase known as START (Pringle and Hartwell, 1981). At START a yeast cell integrates environmental and internal signals (such as nutrient availability, presence of pheromone, attainment of a critical size, status of the metabolic machinery) and decides whether to enter a new cell cycle or to undertake an alternative developmental program. Several signaling pathways, that act to connect the nutritional status to cellular actions, are briefly outlined. A Growth & Cycle interaction network has been manually curated. More than one fifth of the edges within the Growth & Cycle network connect Growth and Cycle proteins, indicating a strong interconnection between the processes of cell growth and cell cycle. The backbone of the Growth & Cycle network is composed of middle-degree nodes suggesting that it shares some properties with HOT networks. The development of multi-scale modeling and simulation analysis will help to elucidate relevant central features of growth and cycle as well as to identify their system-level properties. Confident collaborative efforts involving different expertises will allow to construct consensus, integrated models effectively linking the processes of cell growth and cell cycle, ultimately contributing to shed more light also on diseases in which an altered proliferation ability is observed, such as cancer"
Keywords:		"Cell Cycle/physiology Gene Expression Regulation, Fungal Models, Biological Protein Interaction Maps Saccharomyces cerevisiae/*cytology/genetics/*metabolism Signal Transduction Systems Biology;"
Notes:		"MedlineAlberghina, Lilia Mavelli, Gabriella Drovandi, Guido Palumbo, Pasquale Pessina, Stefania Tripodi, Farida Coccetti, Paola Vanoni, Marco eng Research Support, Non-U.S. Gov't Review England 2011/08/09 Biotechnol Adv. 2012 Jan-Feb; 30(1):52-72. doi: 10.1016/j.biotechadv.2011.07.010. Epub 2011 Jul 22"