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Neuron

Title:		Multimodal Chemosensory Circuits Controlling Male Courtship in Drosophila
Author(s):		Clowney EJ; Iguchi S; Bussell JJ; Scheer E; Ruta V;
Address:		"Laboratory of Neurophysiology and Behavior, The Rockefeller University, New York, NY 10065, USA. Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Laboratory of Neurophysiology and Behavior, The Rockefeller University, New York, NY 10065, USA. Electronic address: ruta@rockefeller.edu"
Journal Title:		Neuron
Year:		2015
Volume:		20150813
Issue:		5
Page Number:		1036 - 1049
DOI:		10.1016/j.neuron.2015.07.025
ISSN/ISBN:		1097-4199 (Electronic) 0896-6273 (Print) 0896-6273 (Linking)
Abstract:		"Throughout the animal kingdom, internal states generate long-lasting and self-perpetuating chains of behavior. In Drosophila, males instinctively pursue females with a lengthy and elaborate courtship ritual triggered by activation of sexually dimorphic P1 interneurons. Gustatory pheromones are thought to activate P1 neurons but the circuit mechanisms that dictate their sensory responses to gate entry into courtship remain unknown. Here, we use circuit mapping and in vivo functional imaging techniques to trace gustatory and olfactory pheromone circuits to their point of convergence onto P1 neurons and reveal how their combined input underlies selective tuning to appropriate sexual partners. We identify inhibition, even in response to courtship-promoting pheromones, as a key circuit element that tunes and tempers P1 neuron activity. Our results suggest a circuit mechanism in which balanced excitation and inhibition underlie discrimination of prospective mates and stringently regulate the transition to courtship in Drosophila"
Keywords:		"Acetylcholine/pharmacology Analysis of Variance Animals Animals, Genetically Modified Arthropod Antennae/cytology Central Nervous System/*cytology Chemoreceptor Cells/drug effects/*physiology *Courtship Drosophila/*physiology Drosophila Proteins/genetics/;neuroscience;"
Notes:		"MedlineClowney, E Josephine Iguchi, Shinya Bussell, Jennifer J Scheer, Elias Ruta, Vanessa eng DP2 NS087942/NS/NINDS NIH HHS/ DP2 NS0879422013/DP/NCCDPHP CDC HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Video-Audio Media 2015/08/19 Neuron. 2015 Sep 2; 87(5):1036-49. doi: 10.1016/j.neuron.2015.07.025. Epub 2015 Aug 13"