| Title: | Yersinia effector YopJ inhibits yeast MAPK signaling pathways by an evolutionarily conserved mechanism |
| Author(s): | Yoon S; Liu Z; Eyobo Y; Orth K; |
| Address: | "Department of Molecular Biology, University of Texas Southwestern Medical School, Dallas 75390-9148, USA" |
| ISSN/ISBN: | 0021-9258 (Print) 0021-9258 (Linking) |
| Abstract: | "Yersinia effector, YopJ, inhibits the innate immune response by blocking MAP kinase and NFkappaB signaling pathways in mammalian cells. Herein, YopJ is shown to disrupt the MAP kinase signaling pathways in Saccharomyces cerevisiae. Expression of YopJ in yeast blocks the ability of yeast to respond to alpha factor by disrupting activation of the pheromone signaling pathway upstream of the activation of the MAPK Fus3p. YopJ also blocks the high osmolarity growth (HOG) MAP kinase pathway in yeast upstream of the activation of the MAPK Hog1p. YopJ is proposed to block the MAP kinase pathways in yeast in a similar manner to the way it blocks mammalian signaling pathways, implicating that a novel, evolutionarily conserved mechanism of regulation is utilized for signal transduction by these pathways" |
| Keywords: | "Bacterial Proteins/*physiology Dose-Response Relationship, Drug Genetic Vectors *MAP Kinase Signaling System Models, Biological NF-kappa B/metabolism Osmotic Pressure Pheromones/metabolism Phosphorylation Saccharomyces cerevisiae/metabolism Signal Transdu;" |
| Notes: | "MedlineYoon, Sara Liu, Zhengchang Eyobo, Yvonne Orth, Kim eng Research Support, Non-U.S. Gov't 2002/11/16 J Biol Chem. 2003 Jan 24; 278(4):2131-5. doi: 10.1074/jbc.M209905200. Epub 2002 Nov 13" |
