| Title: | Volatile organic compounds as a potential screening tool for neoplasm of the digestive system: a meta-analysis |
| Author(s): | Wang L; Li J; Xiong X; Hao T; Zhang C; Gao Z; Zhong L; Zhao Y; |
| Address: | "Department of Nuclear Medicine, The Second Hospital of Jilin University, Changchun, 130041, China. Gastroenterology and Center of Digestive Endoscopy, The Second Hospital of Jilin University, Changchun, 130041, China. Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, 130041, China. zhongll@jlu.edu.cn. Department of Nuclear Medicine, The Second Hospital of Jilin University, Changchun, 130041, China. yinlong@jlu.edu.cn" |
| DOI: | 10.1038/s41598-021-02906-8 |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "This meta-analysis was aimed to estimate the diagnostic performance of volatile organic compounds (VOCs) as a potential novel tool to screen for the neoplasm of the digestive system. An integrated literature search was performed by two independent investigators to identify all relevant studies investigating VOCs in diagnosing neoplasm of the digestive system from inception to 7th December 2020. STATA and Revman software were used for data analysis. The methodological quality of each study was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. A bivariate mixed model was used and meta-regression and subgroup analysis were performed to identify possible sources of heterogeneity. A total of 36 studies comprised of 1712 cases of neoplasm and 3215 controls were included in our meta-analysis. Bivariate analysis showed a pooled sensitivity of 0.87 (95% confidence interval (CI) 0.83-0.90), specificity of 0.86 (95% CI 0.82-0.89), a positive likelihood ratio of 6.18 (95% CI 4.68-8.17), and a negative likelihood ratio of 0.15 (95% CI 0.12-0.20). The diagnostic odds ratio and the area under the summary ROC curve for diagnosing neoplasm of the digestive system were 40.61 (95% CI 24.77-66.57) and 0.93 (95% CI 0.90-0.95), respectively. Our analyses revealed that VOCs analysis could be considered as a potential novel tool to screen for malignant diseases of the digestive system" |
| Keywords: | "*Biomarkers, Tumor Digestive System Neoplasms/*diagnosis/etiology/*metabolism Humans Odds Ratio Prognosis Publication Bias Sensitivity and Specificity Volatile Organic Compounds/*metabolism;" |
| Notes: | "MedlineWang, Lixing Li, Junan Xiong, Xiaoliang Hao, Tingting Zhang, Chao Gao, Zhao Zhong, Lili Zhao, Yinlong eng Meta-Analysis Research Support, Non-U.S. Gov't England 2021/12/11 Sci Rep. 2021 Dec 9; 11(1):23716. doi: 10.1038/s41598-021-02906-8" |
