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IET Syst Biol

Title:		Alternative cell polarity behaviours arise from changes in G-protein spatial dynamics
Author(s):		Chou CS; Moore TI; Nie Q; Yi TM;
Address:
Journal Title:		IET Syst Biol
Year:		2015
Volume:		9
Issue:		2
Page Number:		52 - 63
DOI:		10.1049/iet-syb.2013.0018
ISSN/ISBN:		1751-8849 (Print) 1751-8857 (Electronic) 1751-8849 (Linking)
Abstract:		"Yeast cells form a single mating projection when exposed to mating pheromone, a classic example of cell polarity. Prolonged treatment with pheromone or specific mutations results in alternative cell polarity behaviours. The authors performed mathematical modelling to investigate these unusual cell morphologies from the perspective of balancing spatial amplification (i.e. positive feedback that localises components) with spatial tracking (i.e. negative feedback that allows sensing of gradient). First, they used generic models of cell polarity to explore different cell polarity behaviours that arose from changes in the model spatial dynamics. By exploring the positive and negative feedback loops in each stage of a two-stage model, they simulated a variety of cell morphologies including single bending projections, single straight projections, periodic multiple projections and simultaneous double projections. In the second half of the study, they used a two-stage mechanistic model of yeast cell polarity focusing on G-protein signalling to integrate the modelling results more closely with the authors' previously published experimental observations. In summary, the combination of modelling and experiments describes how yeast cells exhibit a diversity of cell morphologies arising from two-stage G-protein signalling dynamics modulated by positive and negative feedbacks"
Keywords:		"Adaptor Proteins, Signal Transducing/*physiology Cell Polarity/*physiology Computer Simulation Feedback, Physiological/physiology GTP-Binding Proteins/*physiology Mechanotransduction, Cellular/*physiology *Models, Biological Saccharomyces cerevisiae/*phys;"
Notes:		"MedlineChou, Ching-Shan Moore, Travis I Nie, Qing Yi, Tau-Mu eng P50GM76516/GM/NIGMS NIH HHS/ R01GM75309/GM/NIGMS NIH HHS/ R01 GM075309/GM/NIGMS NIH HHS/ T32 HD060555/HD/NICHD NIH HHS/ HD060555-01/HD/NICHD NIH HHS/ P50 GM076516/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. England 2015/06/02 IET Syst Biol. 2015 Apr; 9(2):52-63. doi: 10.1049/iet-syb.2013.0018"