| Title: | The use of a portable breath analysis device in monitoring type 1 diabetes patients in a hypoglycaemic clamp: validation with SIFT-MS data |
| Author(s): | Walton C; Patel M; Pitts D; Knight P; Hoashi S; Evans M; Turner C; |
| Address: | "Cranfield University, Cranfield, Bedfordshire, MK43 0AL, UK" |
| DOI: | 10.1088/1752-7155/8/3/037108 |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Linking) |
| Abstract: | "Monitoring blood glucose concentrations is a necessary but tedious task for people suffering from diabetes. It has been noted that breath in people suffering with diabetes has a different odour and thus it may be possible to use breath analysis to monitor the blood glucose concentration. Here, we evaluate the analysis of breath using a portable device containing a single mixed metal oxide sensor during hypoglycaemic glucose clamps and compare that with the use of SIFT-MS described in previously published work on the same set of patients. Outputs from both devices have been correlated with the concentration of blood glucose in eight volunteers suffering from type 1 diabetes mellitus. The results demonstrate that acetone as measured by SIFT-MS and the sensor output from the breath sensing device both correlate linearly with blood glucose; however, the sensor response and acetone concentrations differ greatly between patients with the same blood glucose. It is therefore unlikely that breath analysis can entirely replace blood glucose testing" |
| Keywords: | "Acetone/analysis Blood Glucose/analysis Breath Tests/*instrumentation/*methods Calibration Diabetes Mellitus, Type 1/*diagnosis Exhalation Glucose Clamp Technique/*instrumentation Humans Ions Mass Spectrometry/*instrumentation Middle Aged Monitoring, Ambu;" |
| Notes: | "MedlineWalton, C Patel, M Pitts, D Knight, P Hoashi, S Evans, M Turner, C eng Wellcome Trust/United Kingdom Clinical Trial Research Support, Non-U.S. Gov't England 2014/09/06 J Breath Res. 2014 Sep; 8(3):037108. doi: 10.1088/1752-7155/8/3/037108. Epub 2014 Sep 4" |
