| Title: | Assessment of selected Saudi and Yemeni plants for mosquitocidal activities against the yellow fever mosquito Aedes aegypti |
| Author(s): | Al-Massarani S; El-Shaibany A; Tabanca N; Ali A; Estep AS; Becnel JJ; Goger F; Demirci B; El-Gamal A; Baser KHC; |
| Address: | "Department of Pharmacognosy, Pharmacy College, King Saud University, Saudi Arabia. Department of Pharmacognosy, Faculty of Pharmacy, University of Sana'a, Yemen. USDA-ARS, Subtropical Horticulture Research Station, Miami, FL 33158, USA. National Center for Natural Products Research, The University of Mississippi, University, MS 38677, USA. Navy Entomology Center of Excellence, Research & Development Department, 1700 SW 23rd Drive, Gainesville, FL 32608, USA. USDA-ARS, Center for Medical, Agricultural, and Veterinary Entomology, 1700 SW 23rd Drive, Gainesville, FL 32608, USA. Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey. Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt. Department of Pharmacognosy, Faculty of Pharmacy, Near East University, Lefkosa (Nicosia), N. Cyprus, Mersin 10, Turkey" |
| DOI: | 10.1016/j.jsps.2019.07.001 |
| ISSN/ISBN: | 1319-0164 (Print) 2213-7475 (Electronic) 1319-0164 (Linking) |
| Abstract: | "As part of our continuing investigation for interesting biological activities of native medicinal plants, thirty-nine plants, obtained from diverse areas in Saudi Arabia and Yemen, were screened for insecticidal activity against yellow fever mosquito Aedes aegypti (L.). Out of the 57 organic extracts, Saussurea lappa, Ocimum tenuiflorum, Taraxacum officinale, Nigella sativa, and Hyssopus officinalis exhibited over 80% mortality against adult female Ae. aegypti at 5?ª+mug/mosquito. In the larvicidal bioassay, the petroleum ether extract of Aloe perryi flowers showed 100% mortality at 31.25?ª+ppm against 1st instar Ae. aegypti larvae. The ethanol extract of Saussurea lappa roots was the second most active displaying 100% mortality at 125 and 62.5?ª+ppm. Polar active extracts were processed using LC-MS/MS to identify bioactive compounds. The apolar A. perryi flower extract was analyzed by headspace SPME-GC/MS analysis. Careful examination of the mass spectra and detailed interpretation of the fragmentation pattern allowed the identification of various biologically active secondary metabolites. Some compounds such as caffeic and quinic acid and their glycosides were detected in most of the analyzed fractions. Additionally, luteolin, luteolin glucoside, luteolin glucuronide and diglucuronide were also identified as bioactive compounds in several HPLC fractions. The volatile ketone, 6-methyl-5-hepten-2-one was identified from A. perryi petroleum ether fraction as a major compound" |
| Keywords: | 6-Methyl-5-hepten-2-one Aedes aegypti Aloe perryi volatile constituents Flavonoids Headspace-SPME Lc-ms/ms Medicinal plants Mosquito control Phenolic acids; |
| Notes: | "PubMed-not-MEDLINEAl-Massarani, Shaza El-Shaibany, Amina Tabanca, Nurhayat Ali, Abbas Estep, Alden S Becnel, James J Goger, Fatih Demirci, Betul El-Gamal, Ali Baser, K Husnu Can eng Saudi Arabia 2020/01/31 Saudi Pharm J. 2019 Nov; 27(7):930-938. doi: 10.1016/j.jsps.2019.07.001. Epub 2019 Jul 4" |
