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Plant Cell

Title:		Plants Release Precursors of Histone Deacetylase Inhibitors to Suppress Growth of Competitors
Author(s):		Venturelli S; Belz RG; Kamper A; Berger A; von Horn K; Wegner A; Bocker A; Zabulon G; Langenecker T; Kohlbacher O; Barneche F; Weigel D; Lauer UM; Bitzer M; Becker C;
Address:		"Department of Internal Medicine I, Medical University Clinic, University of Tubingen, 72076 Tubingen, Germany. Agroecology Unit, University of Hohenheim, Institute of Plant Production and Agroecology in the Tropics and Subtropics, 70593 Stuttgart, Germany. Applied Bioinformatics, University of Tubingen, 72076 Tubingen, Germany. Evotec AG, 22419 Hamburg, Germany. Ecology and Evolutionary Biology Section, Institut de Biologie de l'Ecole Normale Superieure, Ecole Normale Superieure, Inserm U1024, CNRS UMR 8197, 75005 Paris, France. Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany. Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany claude.becker@tuebingen.mpg.de"
Journal Title:		Plant Cell
Year:		2015
Volume:		20151103
Issue:		11
Page Number:		3175 - 3189
DOI:		10.1105/tpc.15.00585
ISSN/ISBN:		1532-298X (Electronic) 1040-4651 (Print) 1040-4651 (Linking)
Abstract:		"To secure their access to water, light, and nutrients, many plant species have developed allelopathic strategies to suppress competitors. To this end, they release into the rhizosphere phytotoxic substances that inhibit the germination and growth of neighbors. Despite the importance of allelopathy in shaping natural plant communities and for agricultural production, the underlying molecular mechanisms are largely unknown. Here, we report that allelochemicals derived from the common class of cyclic hydroxamic acid root exudates directly affect the chromatin-modifying machinery in Arabidopsis thaliana. These allelochemicals inhibit histone deacetylases both in vitro and in vivo and exert their activity through locus-specific alterations of histone acetylation and associated gene expression. Our multilevel analysis collectively shows how plant-plant interactions interfere with a fundamental cellular process, histone acetylation, by targeting an evolutionarily highly conserved class of enzymes"
Keywords:		"Acetylation/drug effects Arabidopsis/drug effects/enzymology/genetics/*growth & development Gene Expression Regulation, Plant/drug effects Genetic Loci Herbicides/pharmacology Histone Deacetylase Inhibitors/chemistry/*pharmacology Histone Deacetylases/*me;"
Notes:		"MedlineVenturelli, Sascha Belz, Regina G Kamper, Andreas Berger, Alexander von Horn, Kyra Wegner, Andre Bocker, Alexander Zabulon, Gerald Langenecker, Tobias Kohlbacher, Oliver Barneche, Fredy Weigel, Detlef Lauer, Ulrich M Bitzer, Michael Becker, Claude eng Research Support, Non-U.S. Gov't England 2015/11/05 Plant Cell. 2015 Nov; 27(11):3175-89. doi: 10.1105/tpc.15.00585. Epub 2015 Nov 3"