| Title: | A Search for CD36 Ligands from Flavor Volatiles in Foods with an Aldehyde Moiety: Identification of Saturated Aliphatic Aldehydes with 9-16 Carbon Atoms as Potential Ligands of the Receptor |
| Author(s): | Tsuzuki S; Amitsuka T; Okahashi T; Kimoto Y; Inoue K; |
| Address: | "R&D Center, T. Hasegawa Company, Ltd. , 29-7 Kariyado, Nakahara-ku, Kawasaki, Kanagawa 211-0022, Japan" |
| ISSN/ISBN: | 1520-5118 (Electronic) 0021-8561 (Linking) |
| Abstract: | "Volatile compounds with an aldehyde moiety such as (Z)-9-octadecenal are potential ligands for cluster of differentiation 36 (CD36), a transmembrane receptor that has recently been shown to play a role in mammalian olfaction. In this study, by performing an assay using a peptide mimic of human CD36, we aimed to discover additional ligands for the receptor from volatiles containing a single aldehyde group commonly found in human foods. Straight-chain, saturated aliphatic aldehydes with 9-16 carbons exhibited CD36 ligand activities, albeit to varying degrees. Notably, the activities of tridecanal and tetradecanal were higher than that of oleic acid, the most potent ligand among the fatty acids tested. Among the aldehydes other than aliphatic aldehydes, only phenylacetaldehyde showed a weak activity. These findings make a contribution to our knowledge of recognition mechanisms for flavor volatiles in foods with an aldehyde group" |
| Keywords: | Aldehydes/*chemistry Animals CD36 Antigens/*chemistry Flavoring Agents/*chemistry Humans Ligands Mice Peptides/chemistry/metabolism Protein Binding Volatile Organic Compounds/*chemistry Cd36 flavor volatiles human diets ligand assessment saturated aliphat; |
| Notes: | "MedlineTsuzuki, Satoshi Amitsuka, Takahiko Okahashi, Tatsuya Kimoto, Yusaku Inoue, Kazuo eng 2017/07/07 J Agric Food Chem. 2017 Aug 9; 65(31):6647-6655. doi: 10.1021/acs.jafc.7b01890. Epub 2017 Jul 25" |
