| Title: | The rich non-coding RNA landscape of the Drosophila antenna |
| Address: | "Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA. Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA. Electronic address: john.carlson@yale.edu" |
| DOI: | 10.1016/j.celrep.2023.112482 |
| Abstract: | "Emerging evidence suggests that long non-coding RNAs (lncRNAs) play diverse and critical roles in neural development, function, and disease. Here, we examine neuronal lncRNAs in a model system that offers enormous advantages for deciphering their functions: the Drosophila olfactory system. This system is numerically simple, its neurons are exquisitely well defined, and it drives multiple complex behaviors. We undertake a comprehensive survey of linear and circular lncRNAs in the Drosophila antenna and identify a wealth of lncRNAs enriched in it. We generate an unprecedented lncRNA-to-neuron map, which reveals that olfactory receptor neurons are defined not only by their receptors but also by the combination of lncRNAs they express. We identify species-specific lncRNAs, including many that are expressed primarily in pheromone-sensing neurons and that may act in modulation of pheromonal responses or in speciation. This resource opens many new opportunities for investigating the roles of lncRNAs in the nervous system" |
| Keywords: | "Animals Drosophila/genetics *RNA, Long Noncoding/genetics *Olfactory Receptor Neurons CP: Neuroscience Drosophila antenna antennal RNA circular RNA intronic RNA long non-coding RNA olfaction olfactory receptor neurons;" |
| Notes: | "MedlineTalross, Gaelle J S Carlson, John R eng F32 DC019302/DC/NIDCD NIH HHS/ R01 DC002174/DC/NIDCD NIH HHS/ R01 DC004729/DC/NIDCD NIH HHS/ R01 DC011697/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural 2023/05/11 Cell Rep. 2023 May 30; 42(5):112482. doi: 10.1016/j.celrep.2023.112482. Epub 2023 May 10" |
