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Atmos Environ (1994)

Title:		Trends of VOC exposures among a nationally representative sample: Analysis of the NHANES 1988 through 2004 data sets
Author(s):		Su FC; Mukherjee B; Batterman S;
Address:		"Environmental Health Sciences, School of Public Health, University of Michigan, MI, USA. Biostatistics, School of Public Health, University of Michigan, MI, USA"
Journal Title:		Atmos Environ (1994)
Year:		2011
Volume:		45
Issue:		28
Page Number:		4858 - 4867
DOI:		10.1016/j.atmosenv.2011.06.016
ISSN/ISBN:		1352-2310 (Print) 1352-2310 (Linking)
Abstract:		"Exposures to volatile organic compounds (VOCs) are ubiquitous due to emissions from personal, commercial and industrial products, but quantitative and representative information regarding long term exposure trends is lacking. This study characterizes trends from1988 to 2004 for the 15 VOCs measured in blood in five cohorts of the National Health and Nutrition Examination Survey (NHANES), a large and representative sample of U.S. adults. Trends were evaluated at various percentiles using linear quantile regression (QR) models, which were adjusted for solvent-related occupations and cotinine levels. Most VOCs showed decreasing trends at all quantiles, e.g., median exposures declined by 2.5 (m, p-xylene) to 6.4 (tetrachloroethene) percent per year over the 15 year period. Trends varied by VOC and quantile, and were grouped into three patterns: similar decreases at all quantiles (including benzene, toluene); most rapid decreases at upper quantiles (ethylbenzene, m, p-xylene, o-xylene, styrene, chloroform, tetrachloroethene); and fastest declines at central quantiles (1,4-dichlorobenzene). These patterns reflect changes in exposure sources, e.g., upper-percentile exposures may result mostly from occupational exposure, while lower percentile exposures arise from general environmental sources. Both VOC emissions aggregated at the national level and VOC concentrations measured in ambient air also have declined substantially over the study period and are supportive of the exposure trends, although the NHANES data suggest the importance of indoor sources and personal activities on VOC exposures. While piecewise QR models suggest that exposures of several VOCs decreased little or any during the 1990's, followed by more rapid decreases from 1999 to 2004, questions are raised concerning the reliability of VOC data in several of the NHANES cohorts and its applicability as an exposure indicator, as demonstrated by the modest correlation between VOC levels in blood and personal air collected in the 1999/2000 cohort. Despite some limitations, the NHANES data provides a unique, long term and direct measurement of VOC exposures and trends"
Keywords:		Air sampling Blood Exposure Nhanes Quantile regression Trends Volatile organic compounds;
Notes:		"PubMed-not-MEDLINESu, Feng-Chiao Mukherjee, Bhramar Batterman, Stuart eng P30 ES017885/ES/NIEHS NIH HHS/ England 2011/09/01 Atmos Environ (1994). 2011 Sep; 45(28):4858-4867. doi: 10.1016/j.atmosenv.2011.06.016"