| Title: | Status of selected ion flow tube MS: accomplishments and challenges in breath analysis and other areas |
| Address: | "Institute for Science & Technology in Medicine, School of Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB, UK. J Heyrovsky Institute of Physical Chemistry of Science, Academy of Science of the Czech Republic, Dolejskova 3, 18223 Prague 8, Prague, Czech Republic" |
| ISSN/ISBN: | 1757-6199 (Electronic) 1757-6180 (Linking) |
| Abstract: | "This article reflects our observations of recent accomplishments made using selected ion flow tube MS (SIFT-MS). Only brief descriptions are given of SIFT-MS as an analytical method and of the recent extensions to the underpinning analytical ion chemistry required to realize more robust analyses. The challenge of breath analysis is given special attention because, when achieved, it renders analysis of other air media relatively straightforward. Brief overviews are given of recent SIFT-MS breath analyses by leading research groups, noting the desirability of detection and quantification of single volatile biomarkers rather than reliance on statistical analyses, if breath analysis is to be accepted into clinical practice. A 'strengths, weaknesses, opportunities and threats' analysis of SIFT-MS is made, which should help to increase its utility for trace gas analysis" |
| Keywords: | Acetonitriles/analysis Biomarkers/analysis Breath Tests/*instrumentation Colorectal Neoplasms/diagnosis Equipment Design Feces/chemistry Humans Inflammatory Bowel Diseases/diagnosis Malondialdehyde/analysis Mass Spectrometry/*instrumentation Volatile Orga; |
| Notes: | "MedlineSmith, David Spanel, Patrik eng England 2016/05/24 Bioanalysis. 2016 Jun; 8(11):1183-201. doi: 10.4155/bio-2016-0038. Epub 2016 May 23" |
