| Title: | Physicochemical and toxicological properties of wood smoke particulate matter as a function of wood species and combustion condition |
| Author(s): | Singh D; Tassew DD; Nelson J; Chalbot MG; Kavouras IG; Tesfaigzi Y; Demokritou P; |
| Address: | "Center for Nanotechnology and Nanotoxicology, Harvard T.H. Chan School of Public Health, Harvard University, 665 Huntington Ave., Boston, MA 02115, USA; Nanoscience and Advanced Materials Center, Environmental and Occupational Health Sciences Institute, School of Public Health, Rutgers University, 170 Frelinghuysen Rd, Piscataway, NJ 08854, USA. Brigham and Women's Hospital, Pulmonary and Critical Care Medicine, 75 Francis Street, Boston, MA 02115, USA. Department of Environmental Health Sciences, University of Alabama at Birmingham, 1600 University Blvd, Birmingham, AL 35216, USA. Department of Environmental, Occupational, and Geospatial Health Sciences, CUNY Graduate School of Public Health & Health Policy, 55 West 125th Street, New York, NY 10027, USA. Brigham and Women's Hospital, Pulmonary and Critical Care Medicine, 75 Francis Street, Boston, MA 02115, USA. Electronic address: ytesfaigzi@bwh.harvard.edu. Center for Nanotechnology and Nanotoxicology, Harvard T.H. Chan School of Public Health, Harvard University, 665 Huntington Ave., Boston, MA 02115, USA; Nanoscience and Advanced Materials Center, Environmental and Occupational Health Sciences Institute, School of Public Health, Rutgers University, 170 Frelinghuysen Rd, Piscataway, NJ 08854, USA. Electronic address: pdemokri@hsph.harvard.edu" |
| DOI: | 10.1016/j.jhazmat.2022.129874 |
| ISSN/ISBN: | 1873-3336 (Electronic) 0304-3894 (Print) 0304-3894 (Linking) |
| Abstract: | "Wood burning is a major source of ambient particulate matter (PM) and has been epidemiologically linked to adverse pulmonary health effects, however the impact of fuel and burning conditions on PM properties has not been investigated systematically. Here, we employed our recently developed integrated methodology to characterize the physicochemical and biological properties of emitted PM as a function of three common hardwoods (oak, cherry, mesquite) and three representative combustion conditions (flaming, smoldering, incomplete). Differences in PM and off-gas emissions (aerosol number/mass concentrations; carbon monoxide; volatile organic compounds) as well as inorganic elemental composition and organic carbon functional content of PM(0.1) were noted between wood types and combustion conditions, although the combustion scenario exerted a stronger influence on the emission profile. More importantly, flaming combustion PM(0.1) from all hardwoods significantly stimulated the promoter activity of Sterile Alpha Motif (SAM) pointed domain containing ETS (E-twenty-six) Transcription Factor (SPDEF) in human embryonic kidney 293 (HEK-293 T) cells, a biomarker for mucin gene expression associated with mucus production in pulmonary diseases. However, no bioactivity was observed for smoldering and incomplete combustion, which was likely driven by differences in the organic composition of PM(0.1). Detailed chemical speciation of organic components of wood smoke is warranted to identify the individual compounds that drive specific biological responses" |
| Keywords: | *Air Pollutants/analysis Carbon Monoxide/analysis HEK293 Cells Humans Mucins/analysis Particulate Matter/analysis/toxicity Respiratory Aerosols and Droplets Smoke/analysis Transcription Factors *Volatile Organic Compounds/analysis Wood/chemistry Chemical; |
| Notes: | "MedlineSingh, Dilpreet Tassew, Dereje Damte Nelson, Jordan Chalbot, Marie-Cecile G Kavouras, Ilias G Tesfaigzi, Yohannes Demokritou, Philip eng P30 ES005022/ES/NIEHS NIH HHS/ R01 HL140839/HL/NHLBI NIH HHS/ R01 HL068111/HL/NHLBI NIH HHS/ R01 HL140836/HL/NHLBI NIH HHS/ U24 ES026946/ES/NIEHS NIH HHS/ Research Support, N.I.H., Extramural Netherlands 2022/09/10 J Hazard Mater. 2023 Jan 5; 441:129874. doi: 10.1016/j.jhazmat.2022.129874. Epub 2022 Sep 1" |
