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Zh Evol Biokhim Fiziol

Title:		[Receptors of the serpentine type and heterotrimeric G-proteins of the yeasts: structural-functional organization and molecular action mechanisms]
Author(s):		Shpakov AO;
Address:
Journal Title:		Zh Evol Biokhim Fiziol
Year:		2007
Volume:		43
Issue:		1
Page Number:		3 - 23
DOI:
ISSN/ISBN:		0044-4529 (Print) 0044-4529 (Linking)
Abstract:		"The signal systems of the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, coupled to heterotrimeric G-proteins and sensitive to pheromones and alimentary molecules, are prototypes of hormonal signal systems of the higher vertebrate animals and are widely used in studies on molecular mechanisms of their functioning. This review summarizes and analyzes data on structural-functional organization of the first two components of these systems - receptors of the serpentine type and heterotrimeric G-proteins; mechanisms of functional coupling of receptors and G-proteins both between each other and to other signal proteins are discussed. It has been shown that at the early stages of evolution of signal systems, at the yeast level, various models of transduction of signals into the cell were tested; many of them differ essentially from the classic model of the three-component, G-protein-coupled signal system of the higher vertebrates"
Keywords:		Heterotrimeric GTP-Binding Proteins/*physiology Saccharomyces cerevisiae/*physiology Saccharomyces cerevisiae Proteins/*physiology Schizosaccharomyces/*physiology Schizosaccharomyces pombe Proteins/*physiology Signal Transduction/*physiology;
Notes:		"MedlineShpakov, A O rus Review Russia (Federation) 2007/04/06 Zh Evol Biokhim Fiziol. 2007 Jan-Feb; 43(1):3-23"