| Title: | A primer on pheromone signaling in Caenorhabditis elegans for systems biologists |
| Address: | "Department of Biological Sciences, Department of Physics; Georgia Institute of Technology, Atlanta, GA 30332. patrick.mcgrath@biology.gatech.edu. Department of Molecular Biosciences; Northwestern University, Evanston, IL 60208. ilya.ruvinsky@northwestern.edu" |
| DOI: | 10.1016/j.coisb.2018.08.012 |
| ISSN/ISBN: | 2452-3100 (Print) 2452-3100 (Electronic) 2452-3100 (Linking) |
| Abstract: | "Individuals communicate information about their age, sex, social status, and recent life history with other members of their species through the release of pheromones, chemical signals that elicit behavioral or physiological changes in the recipients. Pheromones provide a fascinating example of information exchange: animals have evolved intraspecific languages in the presence of eavesdroppers and cheaters. In this review, we discuss the recent work using the nematode C. elegans to decipher its chemical language through the analysis of ascaroside pheromones. Genetic dissection has started to identify the enzymes that produce pheromones and the neural circuits that process these signals. Ecological experiments have characterized the biotic environment of C. elegans and its relatives, including ecological relationships with a variety of species that sense or release similar blends of ascarosides. Systems biology approaches should be fruitful in understanding the organization and function of communication systems in C. elegans" |
| Notes: | "PubMed-not-MEDLINEMcGrath, Patrick T Ruvinsky, Ilya eng R01 GM114170/GM/NIGMS NIH HHS/ R01 GM126125/GM/NIGMS NIH HHS/ England 2019/04/16 Curr Opin Syst Biol. 2019 Feb; 13:23-30. doi: 10.1016/j.coisb.2018.08.012. Epub 2018 Aug 31" |
