| Title: | Urine volatile organic compounds as biomarkers for minimal change type nephrotic syndrome |
| Author(s): | Liu D; Zhao N; Wang M; Pi X; Feng Y; Wang Y; Tong H; Zhu L; Wang C; Li E; |
| Address: | "Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: liudeshengmz@sina.com. Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: 767721743Q@qq.com. Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: 1029031687@qq.com. Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: 758819438@qq.com. Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: 1175635758@qq.com. Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: 1206743386@qq.com. Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: 623521637@qq.com. Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: 370774491@qq.com. Department of Critical Care Medicine, The Third Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: changshongwangicu@163.com. Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: enyouli@aliyun.com" |
| Journal Title: | Biochem Biophys Res Commun |
| DOI: | 10.1016/j.bbrc.2017.12.164 |
| ISSN/ISBN: | 1090-2104 (Electronic) 0006-291X (Linking) |
| Abstract: | "Urinary volatile organic compounds (VOCs) profiling has recently received considerable attention because it can be obtained noninvasively and conveniently while it can be successfully used in a variety of diseases and can provide unique biomarkers. The aim of current study was to investigate potential biomarkers between minimal change type nephrotic syndrome (MCNS) and normal. Urinary samples were collected from 38 minimal change type nephrotic syndrome patients and 15 healthy controls. Solid phase microextraction (SPME) and chromatography- mass spectrometry (GC-MS) were used to analysis the urinary metabolites. To deal with the final data, the statistical methods principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLSDA) were performed. Six specific VOC biomarkers were present at abnormal levels in the urine of MCNS patients. These VOCs included trans-2,2-dimethyl-4-decene; pyrrole; carbamic acid, monoammonium salt; 1-butyne, 3,3-dimethyl-; diisopropylamine; and 4-heptanone. These biomarkers may be useful as a new diagnostic method and for monitoring the prognosis for MCNS patients" |
| Keywords: | "Adult Biomarkers/*urine China/epidemiology Female Humans Male Middle Aged Nephrosis, Lipoid/*diagnosis/epidemiology/*urine Prevalence Reproducibility of Results Risk Factors Sensitivity and Specificity Volatile Organic Compounds/*urine Diagnostic method G;" |
| Notes: | "MedlineLiu, Desheng Zhao, Nana Wang, Mingao Pi, Xin Feng, Yue Wang, Yue Tong, Hongshuang Zhu, Lin Wang, Changsong Li, Enyou eng Research Support, Non-U.S. Gov't 2018/01/02 Biochem Biophys Res Commun. 2018 Jan 29; 496(1):58-63. doi: 10.1016/j.bbrc.2017.12.164. Epub 2017 Dec 30" |
