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Neuroscience

Title:		Olfactory discrimination ability of CD-1 mice for a large array of enantiomers
Author(s):		Laska M; Shepherd GM;
Address:		"Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA. Matthias.Laska@med.uni-muenchen.de"
Journal Title:		Neuroscience
Year:		2007
Volume:		20061011
Issue:		1
Page Number:		295 - 301
DOI:		10.1016/j.neuroscience.2006.08.063
ISSN/ISBN:		0306-4522 (Print) 0306-4522 (Linking)
Abstract:		"With use of a conditioning paradigm, the ability of eight CD-1 mice to distinguish between 15 enantiomeric odor pairs was investigated. The results demonstrate a) that CD-1 mice are capable of discriminating between all odor pairs tested, b) that the enantiomeric odor pairs clearly differed in their degree of discriminability and thus in their perceptual similarity, and c) that pre-training with the rewarded stimuli led to improved initial but not terminal or overall performance. A comparison between the proportion of discriminated enantiomeric odor pairs of the CD-1 mice and those of other species tested in earlier studies on the same discrimination tasks (or on subsets thereof) shows a significant positive correlation between discrimination performance and the number of functional olfactory receptor genes. These findings provide the first evidence of a highly developed ability of CD-1 mice to discriminate between an array of non-pheromonal chiral odorants. Further, they suggest that a species' olfactory discrimination capabilities for these odorants may be correlated with its number of functional olfactory receptor genes. The data presented here may provide useful information for the interpretation of findings from electrophysiological or imaging studies in the mouse and the elucidation of odor structure-activity relationships"
Keywords:		"Animals Discrimination, Psychological/*physiology Male Mice *Odorants Psychomotor Performance/physiology Receptors, Odorant/*genetics Smell/*physiology Stereoisomerism Stimulation, Chemical;"
Notes:		"MedlineLaska, M Shepherd, G M eng P01 DC004732/DC/NIDCD NIH HHS/ R01 DC000086/DC/NIDCD NIH HHS/ 5 R01 DC00086-38/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2006/10/19 Neuroscience. 2007 Jan 5; 144(1):295-301. doi: 10.1016/j.neuroscience.2006.08.063. Epub 2006 Oct 11"