| Title: | Urine headspace analysis with field asymmetric ion mobility spectrometry for detection of chronic kidney disease |
| Author(s): | Jokiniitty E; Hokkinen L; Kumpulainen P; Leskinen Y; Lehtimaki T; Oksala N; Roine A; |
| Address: | "Department of Surgery, Faculty of Medicine & Health Technology, Tampere University, Tampere, Finland. Centre for Vascular Surgery & Interventional Radiology, Tampere University Hospital, Tampere, Finland. Department of Internal Medicine, Tampere University Hospital, Tampere, Finland. Department of Clinical Chemistry, Fimlab Laboratories & Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine & Health Technology, Tampere University" |
| ISSN/ISBN: | 1752-0371 (Electronic) 1752-0363 (Linking) |
| Abstract: | "Electronic noses (eNoses) are an emerging class of experimental diagnostic tools. They are based on the detection of volatile organic compounds. Urine is used as sample medium in several publications but neither the effect of chronic kidney disease (CKD) on the analysis nor the potential to detect CKD has been explored. Materials & methods: We utilized an eNose based on field asymmetric ion mobility spectrometry (FAIMS) technology to classify urine samples from CKD patients and controls. Results: We were able to differentiate extremes of kidney function with an accuracy of 81.4%. Conclusion: In this preliminary study, applying eNose technology we were able to distinguish the patients with impaired kidney function from those with normal kidney function" |
| Keywords: | "Adult Aged *Electronic Nose Female Glomerular Filtration Rate/physiology Humans Ion Mobility Spectrometry/*methods Kidney Function Tests/methods Male Middle Aged Renal Insufficiency, Chronic/diagnosis/physiopathology/*urine Reproducibility of Results Sens;" |
| Notes: | "MedlineJokiniitty, Elina Hokkinen, Lauri Kumpulainen, Pekka Leskinen, Yrjo Lehtimaki, Terho Oksala, Niku Roine, Antti eng Research Support, Non-U.S. Gov't England 2020/07/03 Biomark Med. 2020 Jun; 14(8):629-638. doi: 10.2217/bmm-2020-0085. Epub 2020 Jul 2" |
