| Title: | Y not a dead end: epistatic interactions between Y-linked regulatory polymorphisms and genetic background affect global gene expression in Drosophila melanogaster |
| Author(s): | Jiang PP; Hartl DL; Lemos B; |
| Address: | "Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA. pjiang@oeb.harvard.edu" |
| DOI: | 10.1534/genetics.110.118109 |
| ISSN/ISBN: | 1943-2631 (Electronic) 0016-6731 (Print) 0016-6731 (Linking) |
| Abstract: | "The Y chromosome, inherited without meiotic recombination from father to son, carries relatively few genes in most species. This is consistent with predictions from evolutionary theory that nonrecombining chromosomes lack variation and degenerate rapidly. However, recent work has suggested a dynamic role for the Y chromosome in gene regulation, a finding with important implications for spermatogenesis and male fitness. We studied Y chromosomes from two populations of Drosophila melanogaster that had previously been shown to have major effects on the thermal tolerance of spermatogenesis. We show that these Y chromosomes differentially modify the expression of hundreds of autosomal and X-linked genes. Genes showing Y-linked regulatory variation (YRV) also show an association with immune response and pheromone detection. Indeed, genes located proximal to the euchromatin-heterochromatin boundary of the X chromosome appear particularly responsive to Y-linked variation, including a substantial number of odorant-binding genes. Furthermore, the data show significant regulatory interactions between the Y chromosome and the genetic background of autosomes and X chromosome. Altogether, our findings support the view that interpopulation, Y-linked regulatory polymorphisms can differentially modulate the expression of many genes important to male fitness, and they also point to complex interactions between the Y chromosome and genetic background affecting global gene expression" |
| Keywords: | "Animals Drosophila melanogaster/*genetics Epistasis, Genetic/*genetics Female *Gene Expression Profiling Gene Order/genetics Genomics Inbreeding Male Multigene Family/genetics Polymorphism, Genetic/*genetics Tropical Climate X Chromosome/genetics Y Chromo;" |
| Notes: | "MedlineJiang, Pan-Pan Hartl, Daniel L Lemos, Bernardo eng R01 GM084236/GM/NIGMS NIH HHS/ GM084236/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2010/06/17 Genetics. 2010 Sep; 186(1):109-18. doi: 10.1534/genetics.110.118109. Epub 2010 Jun 15" |
