« Previous AbstractTwo possible barriers blocking conjugation between different megakaryotypes of Blepharisma    Next Abstract"Soil burdens of persistent organic pollutants: their levels, fate, and risks. Part iv. Quantification of volatilization fluxes of organochlorine pesticides and polychlorinated biphenyls from contaminated soil surfaces" »

Chem Senses

Title:		"Pretreatment with CP-154526 blocks the modifying effects of alarm pheromone on components of sexual behavior in male, but not in female, rats"
Author(s):		Kobayashi T; Kiyokawa Y; Takeuchi Y; Mori Y;
Address:		"Laboratory of Veterinary Ethology, University of Tokyo, 1-1-1 Yayoi Bunkyo-ku, Tokyo, Japan"
Journal Title:		Chem Senses
Year:		2011
Volume:		20110418
Issue:		7
Page Number:		623 - 632
DOI:		10.1093/chemse/bjr017
ISSN/ISBN:		1464-3553 (Electronic) 0379-864X (Linking)
Abstract:		"We previously demonstrated that an alarm pheromone released from male donor Wistar rats evoked several physiological and behavioral responses in recipient rats. However, the pheromone effects on social behavior were not analyzed. In the present study, we examined whether the alarm pheromone affects sexual behavior in male or female rats. When a pair of male and female subjects was exposed to the alarm pheromone during sexual behavior, the ejaculation latency was elongated, the number of mounts was increased, and the hit rate (number of intromissions/number of mounts and intromissions) was decreased in the male subject. In contrast, female sexual behavior was not affected by the alarm pheromone. When we exposed only the male or female subject of the pair to the pheromone just before sexual behavior, the results were similar: the pheromone effects were evident in male, but not in female, subjects. In addition, when we pretreated with corticotropin-releasing factor (CRF) antagonist (CP-154526) before exposing the male subject to the alarm pheromone, the pheromone effects were attenuated in a dose-dependent manner. These results indicate that the alarm pheromone modifies male, but not female, components of sexual behavior and that CRF participates in the effects"
Keywords:		"Animals Female Male Pheromones/*antagonists & inhibitors/pharmacology Pyrimidines/*pharmacology Pyrroles/*pharmacology Rats Rats, Wistar *Sex Characteristics Sexual Behavior, Animal/*drug effects/physiology;"
Notes:		"MedlineKobayashi, Tatsuya Kiyokawa, Yasushi Takeuchi, Yukari Mori, Yuji eng Research Support, Non-U.S. Gov't England 2011/04/20 Chem Senses. 2011 Sep; 36(7):623-32. doi: 10.1093/chemse/bjr017. Epub 2011 Apr 18"