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Biochem Biophys Res Commun

Title:		Yeast pheromone alpha-factor is synthesized as a high molecular weight precursor
Author(s):		Emter O; Mechler B; Achstetter T; Muller H; Wolf DH;
Address:
Journal Title:		Biochem Biophys Res Commun
Year:		1983
Volume:		116
Issue:		3
Page Number:		822 - 829
DOI:		10.1016/s0006-291x(83)80216-2
ISSN/ISBN:		0006-291X (Print) 0006-291X (Linking)
Abstract:		"The sex pheromone alpha-factor of Saccharomyces cerevisiae, a tridecapeptide of approx. 1,700 molecular weight, was found to be synthesized in vivo as a high molecular weight precursor of Mr = 28,000. Inhibition of N-linked glycosylation by tunicamycin leads to three precursor species of lower molecular weight indicating three carbohydrate residues linked to the alpha-factor precursor molecule. A molecular weight of 18,000 was determined for the unglycosylated molecule"
Keywords:		"Animals Mating Factor Molecular Weight Peptides/*genetics/isolation & purification Pheromones/*genetics Protein Precursors/isolation & purification Protein Processing, Post-Translational/drug effects Saccharomyces cerevisiae/drug effects/*physiology Tunic;"
Notes:		"MedlineEmter, O Mechler, B Achstetter, T Muller, H Wolf, D H eng Research Support, Non-U.S. Gov't 1983/11/15 Biochem Biophys Res Commun. 1983 Nov 15; 116(3):822-9. doi: 10.1016/s0006-291x(83)80216-2"