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Commun Biol

Title:		Pheromone components affect motivation and induce persistent modulation of associative learning and memory in honey bees
Author(s):		Baracchi D; Cabirol A; Devaud JM; Haase A; d'Ettorre P; Giurfa M;
Address:		"Research Centre on Animal Cognition, Center for Integrative Biology, CNRS, University of Toulouse, 118 route de Narbonne, F-31062, Toulouse, Cedex 09, France. david.baracchi@unifi.it. Department of Biology, University of Florence, Via Madonna del Piano, 6, 50019, Sesto Fiorentino, Italy. david.baracchi@unifi.it. Center for Mind/Brain Sciences (CIMeC), University of Trento, Piazza Manifattura 1, I-38068, Rovereto, Italy. Research Centre on Animal Cognition, Center for Integrative Biology, CNRS, University of Toulouse, 118 route de Narbonne, F-31062, Toulouse, Cedex 09, France. Department of Physics, University of Trento, Via Sommarive 14, I-38123, Povo, Italy. Laboratory of Experimental and Comparative Ethology, University of Paris 13, F-93430, Sorbonne Paris Cite, France. Institut Universitaire de France (IUF), Paris, France. Research Centre on Animal Cognition, Center for Integrative Biology, CNRS, University of Toulouse, 118 route de Narbonne, F-31062, Toulouse, Cedex 09, France. martin.giurfa@univ-tlse3.fr. Institut Universitaire de France (IUF), Toulouse, France. martin.giurfa@univ-tlse3.fr. College of Animal Science (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou, 350002, China. martin.giurfa@univ-tlse3.fr"
Journal Title:		Commun Biol
Year:		2020
Volume:		20200817
Issue:		1
Page Number:		447 -
DOI:		10.1038/s42003-020-01183-x
ISSN/ISBN:		2399-3642 (Electronic) 2399-3642 (Linking)
Abstract:		"Since their discovery in insects, pheromones are considered as ubiquitous and stereotyped chemical messengers acting in intraspecific animal communication. Here we studied the effect of pheromones in a different context as we investigated their capacity to induce persistent modulations of associative learning and memory. We used honey bees, Apis mellifera, and combined olfactory conditioning and pheromone preexposure with disruption of neural activity and two-photon imaging of olfactory brain circuits, to characterize the effect of pheromones on olfactory learning and memory. Geraniol, an attractive pheromone component, and 2-heptanone, an aversive pheromone, improved and impaired, respectively, olfactory learning and memory via a durable modulation of appetitive motivation, which left odor processing unaffected. Consistently, interfering with aminergic circuits mediating appetitive motivation rescued or diminished the cognitive effects induced by pheromone components. We thus show that these chemical messengers act as important modulators of motivational processes and influence thereby animal cognition"
Keywords:		Animals Bees/drug effects/*physiology Memory/*drug effects *Motivation/drug effects Neurons/drug effects/physiology Odorants Pheromones/*pharmacology Signal Transduction/drug effects Smell/drug effects;
Notes:		"MedlineBaracchi, David Cabirol, Amelie Devaud, Jean-Marc Haase, Albrecht d'Ettorre, Patrizia Giurfa, Martin eng Research Support, Non-U.S. Gov't England 2020/08/19 Commun Biol. 2020 Aug 17; 3(1):447. doi: 10.1038/s42003-020-01183-x"