| Title: | Sniffing out causes of gastrointestinal disorders: a review of volatile metabolomic biomarkers |
| Author(s): | Ahmed I; Niaz Z; Ewbank F; Akarca D; Felwick R; Furnari M; |
| Address: | "Department of Gastroenterology, Aldara Hospital & Medical Centre, Riyadh, Kingdom of Saudi Arabia. Department of Medicine, Mayo Hospital Lahore, Pakistan. Faculty of Medicine, University of Southampton, Southampton, UK. Department of Gastroenterology, University Hospital Southampton, Southampton, UK. Department of Medicine, University of Genova, Genova, Italy" |
| ISSN/ISBN: | 1752-0371 (Electronic) 1752-0363 (Linking) |
| Abstract: | "Distinct changes can be observed in the odor of human excretions during health and disease. Identifying underlying volatile metabolites responsible for these odorous changes can be correlated with the pathological process within the body. Advances in the technology have enabled us to interpret the volatile signature of these changes in the odor. This has opened a promising area to lay the foundations of a rapid, noninvasive and point of care diagnostic tool. This review explores the diagnostic potential of volatile organic metabolites as novel biomarkers and extends the discussion on the clinical applications of these biomarkers in gastrointestinal disorders" |
| Keywords: | Biomarkers/analysis/*metabolism Breath Tests Feces/chemistry Gas Chromatography-Mass Spectrometry Gastrointestinal Diseases/metabolism/*pathology Humans Inflammatory Bowel Diseases/metabolism/pathology *Metabolomics Odorants/analysis Volatile Organic Comp; |
| Notes: | "MedlineAhmed, Iftikhar Niaz, Zafar Ewbank, Frederick Akarca, Danyal Felwick, Richard Furnari, Manuele eng MC_UP_A060_1103/MRC_/Medical Research Council/United Kingdom MC_UU_00005/2/MRC_/Medical Research Council/United Kingdom Review England 2018/09/08 Biomark Med. 2018 Oct; 12(10):1139-1148. doi: 10.2217/bmm-2018-0074. Epub 2018 Sep 7" |
