| Title: | Chromatin-based reprogramming of a courtship regulator by concurrent pheromone perception and hormone signaling |
| Author(s): | Zhao S; Deanhardt B; Barlow GT; Schleske PG; Rossi AM; Volkan PC; |
| Address: | "Department of Biology, Duke University, Durham, NC 27708, USA. Department of Neurobiology, Duke University, Durham, NC 27708, USA. Department of Biology, New York University, New York, NY 10003, USA" |
| ISSN/ISBN: | 2375-2548 (Electronic) 2375-2548 (Linking) |
| Abstract: | "To increase fitness, animals use both internal and external states to coordinate reproductive behaviors. The molecular mechanisms underlying this coordination remain unknown. Here, we focused on pheromone-sensing Drosophila Or47b neurons, which exhibit age- and social experience-dependent increase in pheromone responses and courtship advantage in males. Fruitless(M) (Fru(M)), a master regulator of male courtship behaviors, drives the effects of social experience and age on Or47b neuron responses and function. We show that simultaneous exposure to social experience and age-specific juvenile hormone (JH) induces chromatin-based reprogramming of fru(M) expression in Or47b neurons. Group housing and JH signaling increase fru(M) expression in Or47b neurons and active chromatin marks at fru(M) promoter. Conversely, social isolation or loss of JH signaling decreases fru(M) expression and increases repressive marks around fru(M) promoter. Our results suggest that fru(M) promoter integrates coincident hormone and pheromone signals driving chromatin-based changes in expression and ultimately neuronal and behavioral plasticity" |
| Keywords: | "Animals Chromatin/genetics *Courtship Drosophila/metabolism *Drosophila Proteins/metabolism Drosophila melanogaster/physiology Hormones Male Nerve Tissue Proteins/genetics Perception Pheromones Sexual Behavior, Animal/physiology Transcription Factors/meta;" |
| Notes: | "MedlineZhao, Songhui Deanhardt, Bryson Barlow, George Thomas Schleske, Paulina Guerra Rossi, Anthony M Volkan, Pelin C eng R01 NS109401/NS/NINDS NIH HHS/ Research Support, N.I.H., Extramural 2020/06/05 Sci Adv. 2020 May 22; 6(21):eaba6913. doi: 10.1126/sciadv.aba6913. eCollection 2020 May" |
