| Title: | The faecal scent of inflammatory bowel disease: Detection and monitoring based on volatile organic compound analysis |
| Author(s): | Bosch S; Wintjens DSJ; Wicaksono A; Kuijvenhoven J; van der Hulst R; Stokkers P; Daulton E; Pierik MJ; Covington JA; de Meij TGJ; de Boer NKH; |
| Address: | "Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Gastroenterology and Hepatology, AG&M research institute, Amsterdam, The Netherlands. Electronic address: s.bosch1@amsterdamumc.nl. MUMC+, Maastricht University, Department of Gastroenterology and Hepatology, Maastricht, The Netherlands. University of Warwick, School of Engineering, Coventry, United Kingdom. Spaarne Gasthuis, Department of Gastroenterology and Hepatology, Hoofddorp and Haarlem, The Netherlands. OLVG West, Department of Gastroenterology and hepatology, Amsterdam, The Netherlands. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pediatric Gastroenterology, AG&M research institute, Amsterdam, The Netherlands. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Gastroenterology and Hepatology, AG&M research institute, Amsterdam, The Netherlands" |
| DOI: | 10.1016/j.dld.2020.03.007 |
| ISSN/ISBN: | 1878-3562 (Electronic) 1590-8658 (Linking) |
| Abstract: | "BACKGROUND: Inflammatory bowel disease (IBD) is diagnosed and monitored using endoscopic assessment, which is invasive and costly. In this study, potential of faecal volatile organic compounds (VOC) analysis for IBD detection and identification of disease activity was evaluated. METHODS: IBD patients visiting outpatient clinics of participating tertiary hospitals were included. Active disease was defined as FCP >/=250 mg/g, remission as FCP <100 mg/g with Harvey Bradshaw Index <4 for Crohn's disease (CD) or Simple Clinical Colitis Activity Index <3 for ulcerative colitis (UC). Healthy controls (HC) were patients without mucosal abnormalities during colonoscopy. Faecal samples were measured using gas chromatography-ion mobility spectrometry. RESULTS: A total of 280 IBD patients collected 107 CDa, 84 CDr, 80 UCa and 63 UCr samples. Additionally, 227 HC provided one faecal sample. UC and CD were discriminated from HC with high accuracy (AUC (95%CI): UCa vs HC 0.96(0.94-0.99); UCr vs HC 0.95(0.93-0.98); CDa vs HC 0.96(0.94-0.99); CDr vs HC 0.95(0.93-0.98)). There were small differences between UC and CD (0.55(0.50-0.6)) and no differences between active disease and remission (UCa vs UCr 0.63(0.44-0.82); CDa vs CDr 0.52(0.39-0.65)). CONCLUSION: Our study outcomes imply that faecal VOC analysis holds potential for identifying biomarkers for IBD detection but not for monitoring disease activity" |
| Keywords: | "Adolescent Adult Aged Aged, 80 and over Biomarkers/analysis Breath Tests Case-Control Studies Colitis, Ulcerative/diagnosis Colonoscopy Crohn Disease/diagnosis Feces/*chemistry Female Humans Inflammatory Bowel Diseases/*diagnosis Ion Mobility Spectrometry;" |
| Notes: | "MedlineBosch, Sofie Wintjens, Dion S J Wicaksono, Alfian Kuijvenhoven, Johan van der Hulst, Rene Stokkers, Pieter Daulton, Emma Pierik, Marieke J Covington, James A de Meij, Tim G J de Boer, Nanne K H eng Multicenter Study Research Support, Non-U.S. Gov't Netherlands 2020/05/14 Dig Liver Dis. 2020 Jul; 52(7):745-752. doi: 10.1016/j.dld.2020.03.007. Epub 2020 May 10" |
