| Title: | Breath analysis in critically ill patients: potential and limitations |
| Author(s): | Schubert JK; Miekisch W; Geiger K; Noldge-Schomburg GF; |
| Address: | "Department of Anaesthesiology and Intensive Care, University of Rostock, Schillingallee 35, 18057 Rostock, Germany. jochen.schubert@med.uni-rostock.de" |
| ISSN/ISBN: | 1473-7159 (Print) 1473-7159 (Linking) |
| Abstract: | "Breath tests are attractive since they are noninvasive and can be repeated frequently in the dynamically changing state of critically ill patients. Volatile organic compounds can be produced anywhere in the body and are transported via the bloodstream and exhaled through the lung. They can reflect physiologic or pathologic biochemical processes such as lipid peroxidation, liver disease, renal failure, allograft rejection, and dextrose or cholesterol metabolism. This review describes the diagnostic potential of endogenous organic volatile substances in the breath of critically ill patients. Since many of these patients require ventilatory support, aspects of breath analysis under mechanical ventilation will be addressed. Analytical procedures, problems concerning the physiologic meaning of breath markers and future developments will be discussed" |
| Keywords: | "Biomarkers/*analysis *Breath Tests Cholesterol/metabolism *Critical Illness Equipment Design Graft Rejection Humans Hydrocarbons/analysis/metabolism Lipid Peroxidation Liver Diseases/metabolism Models, Theoretical Renal Insufficiency/metabolism Respiratio;" |
| Notes: | "MedlineSchubert, Jochen K Miekisch, Wolfram Geiger, Klaus Noldge-Schomburg, Gabriele F E eng Review England 2004/09/07 Expert Rev Mol Diagn. 2004 Sep; 4(5):619-29. doi: 10.1586/14737159.4.5.619" |
