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Brain Struct Funct

Title:		The caudo-ventral pallium is a novel pallial domain expressing Gdf10 and generating Ebf3-positive neurons of the medial amygdala
Author(s):		Ruiz-Reig N; Andres B; Lamonerie T; Theil T; Fairen A; Studer M;
Address:		"Universite Cote d'Azur (UCA), CNRS, Inserm, Institut de Biologie Valrose (iBV), 06108, Nice, France. nuria.ruiz@unice.fr. Instituto de Neurociencias (Consejo Superior de Investigaciones Cientificas-Universidad Miguel Hernandez, CSIC-UMH), 03550, San Juan de Alicante, Spain. nuria.ruiz@unice.fr. Instituto de Neurociencias (Consejo Superior de Investigaciones Cientificas-Universidad Miguel Hernandez, CSIC-UMH), 03550, San Juan de Alicante, Spain. Universite Cote d'Azur (UCA), CNRS, Inserm, Institut de Biologie Valrose (iBV), 06108, Nice, France. Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh, EH8 9XD, UK. , Palau 11, 03550, San Juan de Alicante, Spain. Universite Cote d'Azur (UCA), CNRS, Inserm, Institut de Biologie Valrose (iBV), 06108, Nice, France. michele.studer@unice.fr"
Journal Title:		Brain Struct Funct
Year:		2018
Volume:		20180604
Issue:		7
Page Number:		3279 - 3295
DOI:		10.1007/s00429-018-1687-0
ISSN/ISBN:		1863-2661 (Electronic) 1863-2653 (Linking)
Abstract:		"In rodents, the medial nucleus of the amygdala receives direct inputs from the accessory olfactory bulbs and is mainly implicated in pheromone-mediated reproductive and defensive behaviors. The principal neurons of the medial amygdala are GABAergic neurons generated principally in the caudo-ventral medial ganglionic eminence and preoptic area. Beside GABAergic neurons, the medial amygdala also contains glutamatergic Otp-expressing neurons cells generated in the lateral hypothalamic neuroepithelium and a non-well characterized Pax6-positive population. In the present work, we describe a novel glutamatergic Ebf3-expressing neuronal subpopulation distributed within the periphery of the postero-ventral medial amygdala. These neurons are generated in a pallial domain characterized by high expression of Gdf10. This territory is topologically the most caudal tier of the ventral pallium and accordingly, we named it Caudo-Ventral Pallium (CVP). In the absence of Pax6, the CVP is disrupted and Ebf3-expressing neurons fail to be generated. Overall, this work proposes a novel model of the neuronal composition of the medial amygdala and unravels for the first time a new novel pallial subpopulation originating from the CVP and expressing the transcription factor Ebf3"
Keywords:		"Animals Basal Forebrain/embryology/*metabolism Cell Lineage Corticomedial Nuclear Complex/embryology/*metabolism Gene Expression Regulation, Developmental Gestational Age Glutamic Acid/metabolism Growth Differentiation Factor 10/genetics/*metabolism Mice, ;"
Notes:		"MedlineRuiz-Reig, Nuria Andres, Belen Lamonerie, Thomas Theil, Thomas Fairen, Alfonso Studer, Michele eng BFU2010-17305/Consejo Superior de Investigaciones Cientificas/ ANR-13-BSV4-0011/Agence Nationale de la Recherche/ BFU2007-60263/Consejo Superior de Investigaciones Cientificas/ ANR-11-LABX-0028-01/Agence Nationale de la Recherche/ MR/K013750/1/MRC_/Medical Research Council/United Kingdom Aide Individuelle aux Jeunes Chercheurs 2016/Ville de Nice/ Germany 2018/06/06 Brain Struct Funct. 2018 Sep; 223(7):3279-3295. doi: 10.1007/s00429-018-1687-0. Epub 2018 Jun 4"