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Rev Assoc Med Bras (1992)

Title:		Ion mobility spectrometry: the diagnostic tool of third millennium medicine
Author(s):		Romero KI; Fernandez-Maestre R;
Address:
Journal Title:		Rev Assoc Med Bras (1992)
Year:		2018
Volume:		64
Issue:		9
Page Number:		861 - 868
DOI:		10.1590/1806-9282.64.09.861
ISSN/ISBN:		1806-9282 (Electronic) 0104-4230 (Linking)
Abstract:		"Ion mobility spectrometry (IMS) is a fast, low cost, portable, and sensitive technique that separates ions in a drift tube under the influence of an electric field according to their size and shape. IMS represents a non-invasive and reliable instrumental alternative for the diagnosis of different diseases through the analysis of volatile metabolites in biological samples. IMS has applications in medicine in the study of volatile compounds for the non-invasive diagnose of bronchial carcinoma, chronic obstructive pulmonary disease, and other diseases analysing breath, urine, blood, faeces, and other biological samples. This technique has been used to study complex mixtures such as proteomes, metabolomes, complete organisms like bacteria and viruses, monitor anaesthetic agents, determine drugs, pharmaceuticals, and volatile compounds in human body fluids, and others. Pharmaceutical applications include analysis of over-the-counter-drugs, quality assessment, and cleaning verification. Medical practice needs non-invasive, robust, secure, fast, real-time, and low-cost methods with high sensitivity and compact size instruments to diagnose different diseases and IMS is the diagnostic tool that meets all these requirements of the Medicine of the future"
Keywords:		"Breath Tests/methods Diagnostic Techniques, Respiratory System Humans Ion Mobility Spectrometry/*methods/trends Lung Diseases/diagnosis Medical Illustration Reproducibility of Results Volatile Organic Compounds/analysis;"
Notes:		"MedlineRomero, Katiuska I Fernandez-Maestre, Roberto eng Review Brazil 2019/01/24 Rev Assoc Med Bras (1992). 2018 Sep; 64(9):861-868. doi: 10.1590/1806-9282.64.09.861"