« Previous AbstractChronic risk assessment of exposure to volatile organic compounds in the atmosphere near the largest Mediterranean industrial site    Next AbstractA novel stochastic simulation approach enables exploration of mechanisms for regulating polarity site movement »

J Chromatogr A

Title:		Determination of nicotine and N-nitrosamines in house dust by pressurized liquid extraction and comprehensive gas chromatography--nitrogen chemiluminiscence detection
Author(s):		Ramirez N; Ozel MZ; Lewis AC; Marce RM; Borrull F; Hamilton JF;
Address:		"Department of Analytical Chemistry and Organic Chemistry, Universitat Rovira i Virgili, Tarragona, Spain"
Journal Title:		J Chromatogr A
Year:		2012
Volume:		20111115
Issue:
Page Number:		180 - 187
DOI:		10.1016/j.chroma.2011.11.017
ISSN/ISBN:		1873-3778 (Electronic) 0021-9673 (Linking)
Abstract:		"A novel, highly selective method for the determination of nicotine, N-nitrosamines and tobacco-specific nitrosamines (TSNAs) in indoor dust samples is presented in this study. Samples were extracted by in-cell clean-up pressurized liquid extraction (PLE) that allows high extraction efficiency with moderate consumption of organic solvents. The extracts were analyzed by comprehensive gas chromatography and detected with a nitrogen chemiluminiscence detector (GCxGC-NCD) that provided enhanced selectivity and sensitivity for organic nitrogen containing compounds. Method validation showed good linearity, repeatability and reproducibility (%RSD<8%). Recovery was higher than 80% for most target compounds and limits of detection lower than 16 ng g(-1). The method was used for the determination of the nitrosamine target compounds in house dust samples from both smoking and non-smoking households. All the analytes were found in the samples, nicotine being the most abundant compound in smokers' dust and one of the most abundant in non-smokers' dust. To our knowledge this is the first time that volatile N-nitrosamines and TSNAs have been determined in indoor dust samples. The results demonstrate the presence of these highly carcinogenic compounds in house dust, with inherent human exposure through inhalation and/or involuntary ingestion of house dust"
Keywords:		"Chromatography, Gas/*methods Dust/*analysis Limit of Detection Linear Models Liquid-Liquid Extraction/*methods Luminescent Measurements Nicotine/*analysis Nitrogen/chemistry Nitrosamines/*analysis Reproducibility of Results;"
Notes:		"MedlineRamirez, Noelia Ozel, Mustafa Z Lewis, Alastair C Marce, Rosa M Borrull, Francesc Hamilton, Jacqueline F eng Research Support, Non-U.S. Gov't Netherlands 2011/12/14 J Chromatogr A. 2012 Jan 6; 1219:180-7. doi: 10.1016/j.chroma.2011.11.017. Epub 2011 Nov 15"