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Int J Pediatr Otorhinolaryngol

Title:		Exhaled biomarker pattern is altered in children with obstructive sleep apnoea syndrome
Author(s):		Benedek P; Lazar Z; Bikov A; Kunos L; Katona G; Horvath I;
Address:		"Department of Oto-Rhino-Laryngology and Bronchology, Heim Pal Children's Hospital, 86 Ulloi Str., 1089 Budapest, Hungary. dr.benedek.palma@gmail.com"
Journal Title:		Int J Pediatr Otorhinolaryngol
Year:		2013
Volume:		20130606
Issue:		8
Page Number:		1244 - 1247
DOI:		10.1016/j.ijporl.2013.04.025
ISSN/ISBN:		1872-8464 (Electronic) 0165-5876 (Linking)
Abstract:		"OBJECTIVES: Obstructive sleep apnoea syndrome (OSAS) is a common disorder in children, which is associated with enhanced inflammatory status. Inflammation-associated changes could be monitored by the assessment of exhaled biomarker profile. This study aimed to compare the exhaled biomarker profile in children with OSAS and habitual snorers. METHODS: Eighteen children with OSAS (8 +/- 2 years, mean +/- SD) and ten non-OSAS subjects with habitual snoring (9 +/- 2 years) were recruited. Exhaled breath was collected from the lower airways, processed using an electronic nose (E-nose) and analyzed off-line using principal component analysis, followed by discrimination analysis and logistic regression to build a receiver operating characteristic (ROC) curve. RESULTS: Exhaled biomarker pattern of OSAS patients was discriminated from that of control subjects (p = 0.03, cross-validation accuracy: 64%), ROC curve analysis (area: 0.83) showed 78% sensitivity and 70% specificity. CONCLUSIONS: The altered exhaled biomarker pattern in OSAS might reflect accelerated airway and/or systemic inflammation in diseased state. Breath pattern analysis by an E-nose can serve as a new tool to monitor inflammation in children with OSAS"
Keywords:		"Biomarkers/metabolism Breath Tests Case-Control Studies Child Cross-Sectional Studies Exhalation/*physiology Female Humans Male Polysomnography Principal Component Analysis ROC Curve Sleep Apnea, Obstructive/*metabolism Snoring/metabolism Volatile Organic;"
Notes:		"MedlineBenedek, Palma Lazar, Zsofia Bikov, Andras Kunos, Laszlo Katona, Gabor Horvath, Ildiko eng Research Support, Non-U.S. Gov't Ireland 2013/06/12 Int J Pediatr Otorhinolaryngol. 2013 Aug; 77(8):1244-7. doi: 10.1016/j.ijporl.2013.04.025. Epub 2013 Jun 6"