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Heliyon

Title:		The effects of high-fat foods on gut microbiota and small molecule intestinal gases: release kinetics and distribution in vitro colon model
Author(s):		Li ZT; Wang JW; Hu XH; Zhu L; Jiang Y; Gao MJ; Zhan XB;
Address:		"Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China. School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China"
Journal Title:		Heliyon
Year:		2022
Volume:		20221003
Issue:		10
Page Number:		e10911 -
DOI:		10.1016/j.heliyon.2022.e10911
ISSN/ISBN:		2405-8440 (Print) 2405-8440 (Electronic) 2405-8440 (Linking)
Abstract:		"Profiling intestinal gases and their responses to dietary changes can reveal the products and functions of the gut microbiota and their influence on human health. High-fat foods (HFF) can alter the gut microbiota and its metabolites, posing a potential health risk. However, little is known about the effects of HFF on intestinal gas distribution. Therefore, in this study, we used human fecal microorganisms as strains, an in vitro three-chamber colon model and an intestinal gas array sensor as tools. We performed in vitro fermentation using HFF as the fermentation substrate to reveal the effects of HFF on the kinetics of intestinal gas production and changes in the gut microbiota and its metabolites. We found that dietary fatty acids stimulated the production of H2S and volatile organic compounds in the colon, promoted Firmicutes abundance, and decreased Bacteroidetes abundance. These results highlight the potential role of HFF in altering the gut microbiota and intestinal gas, which can lead to health hazards"
Keywords:		Dietary fats Gastrointestinal diseases Hydrogen sulfide In vitro Intestinal gases Volatile organic compound;
Notes:		"PubMed-not-MEDLINELi, Zhi-Tao Wang, Jia-Wei Hu, Xing-Hai Zhu, Li Jiang, Yun Gao, Min-Jie Zhan, Xiao-Bei eng England 2022/10/18 Heliyon. 2022 Oct 3; 8(10):e10911. doi: 10.1016/j.heliyon.2022.e10911. eCollection 2022 Oct"