| Title: | "Isolation and identification of petromyzestrosterol, a polyhydroxysteroid from sexually mature male sea lamprey (Petromyzon marinus L.)" |
| Author(s): | Li K; Siefkes MJ; Brant CO; Li W; |
| Address: | "Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI 48824, USA" |
| DOI: | 10.1016/j.steroids.2012.03.006 |
| ISSN/ISBN: | 1878-5867 (Electronic) 0039-128X (Linking) |
| Abstract: | "Petromyzestrosterol (1), a novel polyhydroxylated steroid, was identified from water conditioned with sexually mature male sea lamprey (Petromyzon marinus), a jawless vertebrate animal. Along with this novel steroid, two known steroids, 7alpha,12alpha,24-trihydroxy-5alpha-cholan-3-one-24-sulfate (3k PZS) and 7alpha,12alpha,24-trihydroxy-5alpha-cholan-24-sulfate (PZS), were isolated. Structures of these compounds were unequivocally established by spectroscopic analyses and by comparison with spectra of known compounds. Electro-olfactogram recordings (EOG) showed that 1 at nanomolar concentrations was stimulatory for the olfactory epithelium of adult females. 3k PZS, known to function as a male sex pheromone, was more stimulatory than 1 for the female olfactory epithelia. The concentration-response curve of 3k PZS was exponential in shape with steep slopes between 10(-10) and 10(-6) mol L(-1). The concentration-response curve for 1 was shallower than that for 3k PZS" |
| Keywords: | "Animals Chromatography, High Pressure Liquid Female *Lampreys Magnetic Resonance Spectroscopy Male Sex Attractants/chemistry/isolation & purification/pharmacology Smell/drug effects/physiology Sterols/chemistry/*isolation & purification/pharmacology;" |
| Notes: | "MedlineLi, Ke Siefkes, Michael J Brant, Cory O Li, Weiming eng Research Support, Non-U.S. Gov't 2012/04/06 Steroids. 2012 Jun; 77(7):806-10. doi: 10.1016/j.steroids.2012.03.006. Epub 2012 Mar 28" |
