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Biosens Bioelectron

Title:		Integration of a field effect transistor-based aptasensor under a hydrophobic membrane for bioelectronic nose applications
Author(s):		Kuznetsov AE; Komarova NV; Kuznetsov EV; Andrianova MS; Grudtsov VP; Rybachek EN; Puchnin KV; Ryazantsev DV; Saurov AN;
Address:		"Scientific-Manufacturing Complex Technological Centre, 1-7 Shokin Square, Zelenograd, 124498 Moscow, Russian Federation. Electronic address: kae@tcen.ru. Scientific-Manufacturing Complex Technological Centre, 1-7 Shokin Square, Zelenograd, 124498 Moscow, Russian Federation"
Journal Title:		Biosens Bioelectron
Year:		2019
Volume:		20190115
Issue:
Page Number:		29 - 35
DOI:		10.1016/j.bios.2019.01.013
ISSN/ISBN:		1873-4235 (Electronic) 0956-5663 (Linking)
Abstract:		"A new bioelectronic nose based on a field effect transistor coupled with an aptamer as the sensing element was developed. The gas-to-liquid extraction interface required for appropriate aptamer function was integrated into standard CMOS technology. It was developed with the use of a sacrificial aluminium etching technique combined with surface modifications by silanes for wettability control. As a proof of concept, aptamer Van74 for vanillin was immobilized on the sensitive surface of the ISFET. The developed microsystem can selectively detect vanillin vapor in a concentration range from 2.7 ppt to 0.3?ª+ppm, with a detection limit of 2.7 ppt. The sensor was able to detect vanillin in a gas sample obtained from roasted coffee beans. This outcome provides a foundation for developing a new generation of bioelectronic noses for the detection and discrimination of volatile compounds"
Keywords:		"Aptamers, Nucleotide/*chemistry Benzaldehydes/*analysis Biosensing Techniques/*instrumentation *Electronic Nose Equipment Design Hydrophobic and Hydrophilic Interactions Limit of Detection Membranes, Artificial *Transistors, Electronic Volatile Organic Co;"
Notes:		"MedlineKuznetsov, Alexander E Komarova, Natalia V Kuznetsov, Evgeniy V Andrianova, Maria S Grudtsov, Vitaliy P Rybachek, Elena N Puchnin, Kirill V Ryazantsev, Dmitriy V Saurov, Alexander N eng England 2019/01/27 Biosens Bioelectron. 2019 Mar 15; 129:29-35. doi: 10.1016/j.bios.2019.01.013. Epub 2019 Jan 15"