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Brain Res

Title:		Mapping the neural circuit activated by alarm pheromone perception by c-Fos immunohistochemistry
Author(s):		Kiyokawa Y; Kikusui T; Takeuchi Y; Mori Y;
Address:		"Laboratory of Veterinary Ethology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan"
Journal Title:		Brain Res
Year:		2005
Volume:		1043
Issue:		1-Feb
Page Number:		145 - 154
DOI:		10.1016/j.brainres.2005.02.061
ISSN/ISBN:		0006-8993 (Print) 0006-8993 (Linking)
Abstract:		"We previously reported that the alarm pheromones released from stressed male rats exaggerated both behavioral and autonomic (stress-induced hyperthermia) responses in recipient rats that were introduced into a novel environment. Subsequent experiments provided evidence that these alarm pheromones could be divided into two functionally different categories based on the site specificity and testosterone dependency of their production. However, the neural mechanisms underlying these behavioral and physiological responses remain unknown. In the present study, we examined Fos expression in 26 brain sites of the recipient rat 60 min after the exposure to the pheromone that aggravated stress-induced hyperthermia. The alarm pheromone-exposed rats showed a concurrent increase in Fos expression, in contrast to control odor-exposed rats in the anterior division lateral and medial group of the bed nucleus of the stria terminalis, paraventricular nucleus, dorsomedial hypothalamic nucleus, anterodorsal medial, lateral and basolateral amygdaloid nucleus, ventrolateral periaqueductal gray, laterodorsal tegmental nucleus, and locus coeruleus. These results provide information about the neural mechanisms in response to a non-sexual pheromone, i.e., an alarm pheromone, and suggest that the perception of the alarm pheromone is related to stress-responsive brains structures, including the hypothalamus and brainstem, as well as to the amygdaloid nuclei"
Keywords:		"Amygdala/*cytology/physiology Animals *Brain Mapping Fever/physiopathology Immunohistochemistry Male Neural Pathways Neurons/metabolism Odorants Perception/physiology Pheromones/*physiology Proto-Oncogene Proteins c-fos/metabolism Rats Rats, Wistar Septal;"
Notes:		"MedlineKiyokawa, Yasushi Kikusui, Takefumi Takeuchi, Yukari Mori, Yuji eng Research Support, Non-U.S. Gov't Netherlands 2005/05/03 Brain Res. 2005 May 10; 1043(1-2):145-54. doi: 10.1016/j.brainres.2005.02.061"