| Title: | Noninvasive analysis of volatile biomarkers in human emanations for health and early disease diagnosis |
| Author(s): | Kataoka H; Saito K; Kato H; Masuda K; |
| Address: | "School of Pharmacy, Shujitsu University, 1-6-1, Nishigawara, Naka, Okayama 703-8516, Japan. hkataoka@shujitsu.ac.jp" |
| ISSN/ISBN: | 1757-6199 (Electronic) 1757-6180 (Linking) |
| Abstract: | "Early disease diagnosis is crucial for human healthcare and successful therapy. Since any changes in homeostatic balance can alter human emanations, the components of breath exhalations and skin emissions may be diagnostic biomarkers for various diseases and metabolic disorders. Since hundreds of endogenous and exogenous volatile organic compounds (VOCs) are released from the human body, analysis of these VOCs may be a noninvasive, painless, and easy diagnostic tool. Sampling and preconcentration by sorbent tubes/traps and solid-phase microextraction, in combination with GC or GC-MS, are usually used to analyze VOCs. In addition, GC-MS-olfactometry is useful for simultaneous analysis of odorants and odor quality. Direct MS techniques are also useful for the online real-time detection of VOCs. This review focuses on recent developments in sampling and analysis of volatile biomarkers in human odors and/or emanations, and discusses future use of VOC analysis" |
| Keywords: | "Animals Biomarkers/analysis Breath Tests/instrumentation/methods Chromatography, Gas/instrumentation/methods *Early Diagnosis Equipment Design Humans Mass Spectrometry/instrumentation/methods Odorants/*analysis Olfactometry/instrumentation/methods Solid P;" |
| Notes: | "MedlineKataoka, Hiroyuki Saito, Keita Kato, Hisato Masuda, Kazufumi eng Research Support, Non-U.S. Gov't Review England 2013/06/08 Bioanalysis. 2013 Jun; 5(11):1443-59. doi: 10.4155/bio.13.85" |
